HUANG yong

HUANG Yong 黄勇教授.JPG

Ph.D., M.D., Professor, Deputy Dean.

Born in Nov. 1975, China.

Contact

Address: College of Veterinary Medicine, Northwest A&F University

No. 22 Xinong Road, Yangling, 712100, Shaanxi, China.

Email: huangyong@nwafu.edu.cn

Mobile: +86 187 0090 6418

1. Education and Work Experience

2011 – now, Professor, College of Veterinary Medicine, Northwest A&F University

2008 – 2011, Postdoctoral training, The CBER of FDA, Bethesda, U.S.

2004 – 2007, Ph.D., Biochemistry and Molecular Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University

2001 – 2004, M.S., Biochemistry and Molecular Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University

1994 – 1999, M.D., Medicine, Department of medicine, The Tian Jin Medical University

2. Research and Teaching

Research interests:

Infection and Immunity.

Molecular pathology.

Molecular virology.

Vaccine.

Teaching:

Animal Pathological Anatomy

Cellular and Molecular Pathology

3. Memberships and Academic Services

Executive Director of Veterinary Pathology Branch, Chinese Association of Animal Husbandry and Veterinary Medicine.

Standing member of Laboratory Construction and Development Branch of National Health Industry Enterprise Management Association.

Standing director of Shaanxi Province Experimental Animal Association.

Member of Biosafety Expert Committee of Pathogen Microbiology Laboratory of Shaanxi Province.

Member of the 7th Editorial Committee of Chinese Journal of Veterinary Medicine .

Editorial Board member, Advances in Animal Medicine .

Life member of Chinese Association of Microbiology.

Senior member of Chinese Association of Immunology.

Member of Chinese Association of Biochemistry and Molecular Biology.

Communications assessment Specialist of National Natural Science Foundation of China.

Assessment specialist of China Postdoctoral Foundation.

Reviewer in several international journal, such as Journal of Virology , Journal of Immunology , Immunology , Virology , Vaccine , Veterinary Research , Veterinary Microbiology , etc .

4. Honors and Awards

Young and middle-aged leading talents in scientific and technological innovation of Shaanxi Province.

Outstanding Young Talents of Northwest A&F University.

5. Publications

Selected papers:

[1] Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R, Han C, Liu H, Yin X, Du Q, Tong D*, Huang Y*. PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. PLOS pathogens , 17(9), e1009940 (2021).

[2] Wang T, Du Q, Niu Y, Zhang X, Wang Z, Wu X, Yang X, Zhao X, Liu SL, Tong D*, Huang Y*. Cellular p32 is a critical regulator of the porcine circovirus type 2 nuclear egress. Journal of virology , 93(23), e00979-19 (2019).

[3] Wang T, Du Q, Wu X, Niu Y, Guan L, Wang Z, Zhao X, Liu SL, Tong D*, Huang Y*. Porcine MKRN1 Modulates the Replication and Pathogenesis of Porcine Circovirus Type 2 by Inducing Capsid Protein Ubiquitination and Degradation. Journal of virology , 92(11), e00100-18 (2018).

[4] Du Q, Wu X, Wang T, Yang X, Wang Z, Niu Y, Zhao X, Liu SL, Tong D*, Huang Y*. Porcine Circovirus Type 2 Suppresses IL-12p40 Induction via Capsid/gC1qR-Mediated MicroRNAs and Signalings. The Journal of immunology , 201, 533-547 (2018).

[5] Li R, Liu W, Yin X, Zheng F, Wang Z, Wu X, Zhang X, Du Q, Huang Y*, Tong D*. Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production. Frontiers in Microbiology, 12, 702881 (2021).

[6] Du Q, Zhang H, He M, Zhao X, He J, Cui B, Yang X, Tong D*, Huang Y*. Interleukin-10 Promotes Porcine Circovirus Type 2 Persistent Infection in Mice and Aggravates the Tissue Lesions by Suppression of T Cell Infiltration. Frontiers in Microbiology , 10, 2050 (2019).

[7] Cui B, Liu W, Wang X, Chen Y, Du Q, Zhao X, Zhang H, Liu SL, Tong D*, Huang Y*. Brucella Omp25 Upregulates miR-155, miR-21-5p, and miR-23b to Inhibit Interleukin-12 Production via Modulation of Programmed Death-1 Signaling in Human Monocyte/ Macrophages. Frontiers in immunology , 8, 708 (2017).

[8] Luo X, Zhang X, Wu X, Yang X, Han C, Wang Z, Du Q, Zhao X, Liu SL, Tong D*, Huang Y*. Brucella down-regulates TNF-α to promote intracellular survival via Omp25 regulation. Frontiers in immunology , 8, 2013 (2018).

[9] Zhao X, Bai X, Guan L, Li J, Song X, Ma X, Guo J, Zhang Z, Du Q, Huang Y*, Tong D*. microRNA-4331 promotes TGEV-induced mitochondrial damage via targeting RB1, up-regulating IL1RAP, and activating p38 MAPK pathway in vitro. Molecular & Cell Proteomics , 17(2), 190-204 (2018).

[10] Wang X, Wei S, Zhao Y, Shi C, Liu P, Zhang C, Lei Y, Zhang B, Bai B, Huang Y*, Zhang H*. Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death. Cancer Letters , 385, 128-136 (2017).

[11] Xu D, Du Q, Han C, Wang Z, Zhang X, Wang T, Zhao X, Huang Y*, Tong D*. p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. Veterinary Research , 47(1), 120 (2016).

[12] Han C, Du Q, Zhu L, Chen N, Luo L, Chen Q, Yin J, Wu X, Tong D*, Huang Y*. Porcine DNAJB6 promotes PCV2 replication via enhancing the formation of autophagy in host cells. Veterinary Research , 51(1), 61 (2020).

[13] Chen S, Miao B, Chen N, Zhang X, Zhang X, Du Q, Huang Y*, Tong D*. A novel porcine parvovirus DNA-launched infectious clone carrying stable double labels as an effective genetic platform. Veterinary Microbiology , 240, 108502 (2020).

[14] Chen S, Miao B, Zhang H, Xiong Y, Zhang X, Shao T, He J, Du Q, Huang Y*, Tong D*. Construction and characterization of the infectious clone of porcine parvovirus carrying genetic marker. Veterinary Microbiology , 235, 143-150 (2019).

[15] Zhang L, Wang Z, Zhang J, Luo X, Du Q, Chang L, Zhao X, Huang Y*, Tong D*. Porcine Parvovirus infection impairs progesterone production in Luteal Cells through MAPKs, p53 and mitochondria-mediated Apoptosis. Biol Reprod , 98(4), 558-569 (2018).

[16] Zhang X, Xiong Y, Zhang J, Shao T, Chen S, Miao B, Wang Z, Du Q, Huang Y*, Tong D*. Autophagy Promotes Porcine Parvovirus Replication and Induces Non-Apoptotic Cell Death in Porcine Placental Trophoblasts. Viruses , 12(1), 15 (2019).

[17] Wu X, Wang X, Shi T, Luo L, Qiao D, Wang Z, Han C, Du Q, Tong D*, Huang Y*. Porcine Circovirus Type 2 Rep Enhances IL-10 Production in Macrophages via Activation of p38-MAPK Pathway. Viruses , 11(12), 1141 (2019).

[18] Li D, Du Q, Wu B, Li J, Chang L, Zhao X, Huang Y*, Tong D*. Immunogenicity of adenovirus vaccines expressing the PCV2 capsid protein in pigs. Vaccine , 35(36), 4722-4729 (2017).

[19] Huang Y, Lei Y, Zhang H, Zhang M, Dayton A. Interleukin-12 treatment down-regulates STAT4 and induces apoptosis with increasing ROS production in human natural killer cell. Journal of Leukocyte Biology , 90, 87-97 (2011).

[20] Huang Y, Lei Y, Zhang H, Hou L, Zhang M, Dayton A. MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of interleukin-12 signaling in human natural killer cells. Blood , 118(26), 6793-802 (2011).

6. Projects and Funding

[1] The regulation and mechanism of gC1qR/HDAC6 in PCV2 inhibition of cGAS-STING pathway activation. General project, No. 31972686, National Natural Science Foundation of China (NSFC), 2020 - 2023.

[2] The role and regulatory mechanism of gC1qR in PCV2 induced M2-type polarization of macrophages. General project, No. 31672535, National Natural Science Foundation of China (NSFC), 2017 - 2020.

[3] The regulation mechanisms of IL-12-induced microRNAs on the function of NK cells and the development and progression of sepsis. General project, No. 31372411, National Natural Science Foundation of China (NSFC), 2014 - 2017.

[4] Outstanding Young Talents Project, No. 2452017023, Young Talents Cultivation Plan of Northwest A&F University, 2017 - 2019.

[5] The research and development of key technologies for monitoring major diseases in pig breeding. Shaanxi Province Key Industry Innovation Chain (Group) - agricultural project, 2018 - 2020.

[6] The study and demonstration on the early detection of PEDV and TGEV infection by UNDP-PCR. Innovation and tackling of agricultural science and technology in Shaanxi Province, 2015 - 2016.

[7] The key technology of animal husbandry disease control. Innovation and tackling of agricultural science and technology in Shaanxi Province, 2012 - 2013.

[8] The development of brucella milk-goat nano-fluorescence differential diagnosis kit. Xi 'an Science and Technology Planning project, 2021 - 2023.

[9] The molecular mechanism of PCV2 induced hyperexpression of IL-10 in porcine macrophages. Basic research Funds special Funds project, 2015 - 2016.

[10] The molecular regulation of NK cell activity during sepsis formation. Key Project, Science and Technology Innovation of Northwest A&F University, 2013 - 2015.

[11] A new technique for rapid diagnosis of swine epidemic disease. International Science and Technology Cooperation Fund project of Northwest A&F University, 2013 - 2015.

[12] The role and regulatory mechanism of OMP25 in Immune escape of Brucella. Introduction of talents research project of Northwest A&F University, 2011 - 2014.