PENG sha

1. Basic Information 彭莎教授.JPG

PENG Sha, Ph.D., Professor, doctoral supervisor, a council member of the theriogenology division of Chinese association of animal science and veterinary medicine, a member of the of stem cells society of Shaanxi province, a member of the “three zones” scientific and technological talent and correspondent of Shaanxi province, communication review expert of life sciences division of NSFC committee and dissertation of ministry of education, editorial board member of Zoological Research , reviewer of Biomedicine Pharmacotherapy, Stem Cell Report, Gene, Reproduction, Chinese Journal of Biochemistry and Molecular Biology and Progress in Veterinary Medicine.

2. Educational and Research Experience

Educational Experience

2002-2007 Doctor Degree, Reproductive Physiology, Institute of Zoology Chinese Academy of Sciences, Beijing, China

1998-2002 Bachelor Degree, Veterinary Medicine, College of Animal Medicine Northwest A&F University, Yangling, Shaanxi, China

Research Experience

2022–present Professor

2012–2021 Associate Professor

College of Animal Medicine

Northwest A&F University, YangLing, Shaanxi, China

2007–2012 Lecturer

College of Animal Medicine

Northwest A&F University, YangLing, Shaanxi, China

3. Research Field and Courses Offered

Research field：The study and application of adult stem cells, the mechanism of heat stress on spermatogenesis

Courses offered for graduate student: Protein Engineering, Stem Cells and Tissue Engineering.

Courses offered for undergraduate student: Animal Physiology, Animal Physiology Experiment, Animal Embryo Engineering, Introduction of Animal Biotechnology.

4. Research Funding

（1）National Natural Science Foundation of China (general project), 32072815，Protective mechanism of melatonin on goat spermatogenesis disorder under heat stress, 2021/1-2024/12.

（2）Horizontal project of BAIOUPAI (Tianjin) Biotechnology Co., Ltd, K4040121282, Clinical application technology development of pet mesenchymal stem cells, 2021/1-2022/10.

（3）Fundamental research funds for the central universities，2452020157，Mechanism of melatonin in alleviating spermatocyte induced by injury heat stress，2020/06-2023/06.

（4）Horizontal project of Ningbo second hormone factory, 20201214000014, Study on pharmacodynamics and flexible popularization of animal hormone products in sheep rapid propagation and high efficiency reproduction standardization system, 2020/1-2021/12.

（5）Key R & D plan of Shaanxi Province, 2019NY-091，Study on the preventive and therapeutic effects of compound biological preparation on dairy goat SARA and its application, 2019/01-2020/12.

（6）Project of agricultural science and technology innovation and key research of Shaanxi Province，2016NY-094，Research and development of new compound biological preparation for prevention and treatment of piglet diarrhea and its application,2016/01-2017/12.

（7）Start-up funds for returned overseas scholars of the Ministry of Education，K308021501，Regulatory mechanism of miR-375 in proliferation and differentiation of porcine PSCs into insulin secreting cells，2015/1-2017/12.

（8）Preferential funding for science and technology activities of overseas scholars, Z109021506, Mechanism of LncRNA in the proliferation and differentiation of porcine pluripotent stem cells (PSCs), 2015/01-2015/12.

（9）Fundamental research funds for the central universities, 2452015034，Mechanism of miR-375 in the proliferation and differentiation of porcine pluripotent stem cells (PSCs), 2015/01-2017/12.

（10）National Natural Science Foundation of China, 31101775, Mechanism of classical Wnt signaling pathway in the proliferation and differentiation of porcine pluripotent stem cells (PSCs), 2012/01-2014/12.

（11） Doctoral Fund of Ministry of Education of China，20100204120020，Mechanism of Wnt/β-catenin in the proliferation and differentiation of porcine pluripotent stem cells (PSCs), 2011/01-2012/12.

（12）Start-up funds for doctoral research of Northwest A&F University, Study on isolating, culturing amniotic fluid-derived stem cells and directionally differentiate into islet cells, 2008/01-2009/12.

5.Publications

（1）Fen Sun^#, Hui Cai^#, Lunbo Tan, Dezhe Qin, Jian Zhang, Jinlian Hua, Xiujun Fan*，Sha Peng*. Placenta-specific miR-125b overexpression leads to increased rate of pregnancy loss in mice. International journal of molecular sciences. 2022, 23, 943.

（2）Chen He^#, Jing Sun^#, Donghui Yang, Wenlai He, Jingyi Wang, Dezhe Qin, Huimin Zhang, Hui Cai, Yundie Liu, Na Li, Jinlian Hua*, Sha Peng*. Nrf2 activation mediates the protection of mouse Sertoli Cells damage under acute heat stress conditions. Theriogenology. 2022, 177: 183-194.

（3）Dezhe Qin^#, Hui Cai, Chen He, Donghui Yang, Jing Sun, Wenlai He, Balun Li, Jinlian Hua, Sha Peng*. Melatonin relieves heat-induced spermatocyte apoptosis of mouse testis by inhibiting ATF6 and PERK signaling pathways. Zoological Research. 2021, 42(4): 514-524.

（4）Hong Yang^#, Dezhe Qin, Shuanshuan Xu, Chen He, Jing Sun, Jinlian Hua, Sha Peng*. Folic acid promotes proliferation and differentiation of porcine pancreatic stem cells into insulin-secreting cells through canonical Wnt and ERK signaling pathway. Journal of Steroid Biochemistry and Molecular Biology. 2021, 205,105772.

（5）Xiuwei Yu^#, Tongtong Li^#, Xiaomin Du^#, Qiaoyan Shen, Mengfei Zhang, Yudong Wei, Donghui Yang, Wenjing Xu, Wenbo Chen, Chunling Bai, Xueling Li, Guangpeng Li, Na Li, Sha Peng*, Mingzhi Liao*, Jinlian Hua*. Single-cell RNA sequencing reveals atlas of dairy goat testis cells. Zoological Research. 2021, 42(4): 401-405.

（6）Wenlai He^#, Dezhe Qin^#, Balun Li, Huimin Zhang, Xuedi Cheng, Jing Sun, Jinlian Hua, Sha Peng*. Immortalized canine adipose-derived mesenchymal stem cells alleviate gentamicin-induced acute kidney injury by inhibiting endoplasmic reticulum stress in mice and dogs. Research in Veterinary Science. 2021, 136: 39-50.

（7）Hui Cai^#，Dezhe Qin^#, Sha Peng*. Responses and coping methods of different testicular cell types to heat stress: overview and perspectives. Bioscience Reports. 2021, 41(6): BSR20210443.

（8）Shuanshuan Xu^#, Dezhe Qin^#, Hong Yang, Chen He, Wenqing Liu, Na Tian, Yudong Wei, Xin He, Jinlian Hua, Sha Peng*. SerpinB1 promotes the proliferation of porcine pancreatic stem cells through the STAT3 signaling pathway. Journal of Steroid Biochemistry and Molecular Biology. 2020, 198:105537.

（9）Zhaoyu Du^#, Shuanshuan Xu^#, Shuxian Hu, Hong Yang, Zhe Zhou, Kuldip Sidhu, Yiliang Miao, Zhonghua Liu, Wei Shen, Russel J. Reiter, Jinlian Hua*, Sha Peng*. Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining Leydig cells. Cell Death & Disease. 2018, 9: 968.

（10）Hong Yang^#, Xi Yao^#, Furong Tang, Yudong Wei, Jinlian Hua, Sha Peng*, Characterization of female germline stem cells from adult mouse ovaries and the role of rapamycin on them. Cytotechnology. 2018, 70(2): 843-854.

（11）Bo Li^#, Xin He^#, Mengru Zhuang, Bowen Niu, Chongyang Wu, Hailong Mu, Furong Tang, Yanhua Cui, Weishuai Liu, Baoyu Zhao, Sha Peng*, Guangpeng Li*, Jinlian Hua*. Melatonin ameliorates busulfan-induced spermatogonial stem cell oxidative apoptosis in mouse testes. Antioxidants and Redox Signaling. 2018, 28(5): 385-400.

（12）Yanhua Cui^#, Lipeng Ren, Bo Li, Jia Fang, Yuanxin Zhai, Xin He, Enqi Du, Yiliang Miao, Jinlian Hua*, Sha Peng*. Melatonin relieves busulfan-induced spermatogonial stem cell apoptosis of mouse testis by inhibiting endoplasmic reticulum stress. Cellular Physiology and Biochemistry. 2017, 44(6): 2407-2421.

（13）Shuanshuan Xu^#, Fen Sun^#, Lipeng Ren, Hong Yang, Na Tian, Sha Peng*. Resveratrol controlled the fate of porcine pancreatic stem cells through the Wnt/β-catenin signaling pathway mediated by Sirt1. PLOS One. 2017, 12(10): e0187159.

（14）Lipeng Ren^#, Hong Yang^#, Yanhua Cui, Shuanshuan Xu, Fen Sun, Na Tian, Jinlian Hua*, Sha Peng*. Autophagy is essential for differentiation of porcine PSCs into insulin producing cells, Biochemical and Biophysical Research Communications. 2017, 488(3): 471-476.

（15）Shuxian Hu^#, Mingzhi Zhang, Fen Sun, Lipeng Ren, Xin He, Jinlian Hua*, Sha Peng*. miR-375 controls porcine pancreatic stem cell fate by targeting 3-phosphoinositide–dependent protein kinase-1 (Pdk1). Cell Proliferation. 2016, 49(3): 395-406.

（16） Lipeng Ren^#, Wei Han^#, Hong Yang, Fen Sun, Shuanshuan Xu, Shuxian Hu, Mingzhi Zhang, Xin He, Jinlian Hua*, Sha Peng*. Autophagy stimulated proliferation of porcine PSCs might be regulated by the canonical Wnt signaling pathway. Biochemical and Biophysical Research Communications. 2016, 479(3): 537-543.

（17）Wei Han^#, Xin He, Mingzhi Zhang, Shuxian Hu, Fen Sun, Lipeng Ren, Jinlian Hua*, Sha Peng*. The establishment of porcine pancreatic stem cell line using T-REx^TM system-inducible Wnt3a expression. Cell Proliferation. 2015, 48: 301-310.

（18）Xin He^#, Wei Han^#, Shuxian Hu, Mingzhi Zhang, Lipeng Ren, Fen Sun, Jinlian Hua*, Sha Peng*. Canonical Wnt signaling pathway contributes to the proliferation and survival in porcine Pancreatic Stem Cells (PSCs). Cell Tissue Research. 2015, 362(2): 379-388.

（19）Xi Yao^#, Hao Ren, Wenjing Yang, Thirumalai Diraviyam, Furong Tang, Meng Yu, Jinlian Hua, Xiaoying Zhang*, Sha Peng*. Expression of goat RNA binding protein (NANOS2), development and evaluation of anti-NANOS2 IgY antibodies.” Czech Journal of Animal Science. 2015, (4): 152-163.

（20）Xi Yao^#, Furong Tang, Meng Yu, Haijing Zhu, Zhili Chu, Mingzhao Li, Wei Liu*, Jinlian Hua*, Sha Peng*. Expression profile of Nanos2 gene in dairy goat and its inhibitory effect on Stra8 during meiosis. Cell Proliferation, 2014, 47, 396-405.

（21）Sha Peng^#*, Wei Han, Xi Yao, Jinlian Hua*. Construction and identification of mouse R-spondin 1 eukaryotic expression vector. Journal of Food, Agriculture & Environment 2013,11 (1): 227-230.

（22）Huiru Zhang^#, Dan Li, Hui Cao, Xiao LV, Yuankui Chu, Yaofu Bai, Yaping Jin, Sha Peng*, Zhongying Dou, Jinlian Hua*. Conophylline promotes the proliferation of immortalized mesenchymal stem cells derived from fetal porcine pancreas (iPMSCs). Journal of Integrative Agriculture 2013, 12(4): 678-686.

（23）Sha Peng^#*, Junlin Zhang, Jiahuan Chen, Huayan Wang*. Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells. Molecular Medicine Reports. 2011, 4: 99-104.

（24）Sha Peng^#*, Jinlian Hua, Xuanhong Cao, Huayan Wang*. Gelatin Induces Trophectoderm Differentiation of Mouse Embryonic Stem Cells.” Cell Biology International 2011, 35: 587-591.

（25）Jiahuan Chen^#, Zhijuan Lu, De Cheng, Sha Peng*, Huayan Wang*. Isolation and Characterization of Porcine Amniotic Fluid-Derived Multipotent Stem Cells. Plos One. 2011, 6: e19964.

（26）Sha Peng^#, Jing Li, Chenglin Miao, Liwei Jia, Zeng Hu, Ping Zhao, Juxue Li, Ying Zhang, Qi Chen, Enkui Duan*. Dickkopf-1 secreted by decidual cells promotes trophoblast cell invasion during murine placentation. Reproduction. 2008, 135: 367-375.

（27）Sha Peng^#, Chenglin Miao, Jing Li, Xiujun Fan, Yujing Cao, Enkui Duan*. Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling. Biochemical and Biophysical Research Communications. 2006, 350: 641-647.

6. Contact Information

Corresponding address: 22 Xinong Road, Yangling district, Xianyang, China, College of Veterinary Medicine, Northwest A&F University. Postcode: 712100

Email：pengshacxh@163.com