Wang Huayan
Name: Wang Huayan Position: Professor, Director
E-mail: hhwang101@163.com
Work Address: Stem Cell Research Institute, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China
EDUCATION
1978-1982: DVM. of Veterinary Medicine
Department of Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Shaanxi, China
1983-1985: MS. of Biochemistry
Department of Biochemistry, College of Biology, China Agricultural University, Beijing, China
1988-1991: Ph.D. of Molecular and Cellular Biology
Department of Genetics, Trinity College, University of Dublin, Dublin, Ireland
CAREER HIGHLIGHT
2006-present: Professor and Director
Stem Cell Research Institute, Northwest A&F University, Yangling, Shaanxi, China.
2004-2005: Manager
HW MediLane BioScience Inc., Wilmington, DE 19810, USA
2000-2004: Senior Research Scientist
Department of Research and Development, DuPont Pharmaceuticals Co. Wilmington, DE 19880, USA
1998-1999: Research Scientist
Department of Clinical Medical Sciences, DuPont Children Hospital, Wilmington, DE 19803, USA
1993-1997: Research Associate
Department of Biochemistry, Faculty of Medicine, University of Alberta, Alberta, Canada
1991-1992: Postdoctoral Fellow
Department of Biology, Ireland National University, Dublin, Ireland
1985-1988: Biochemist, Junior Faculty Member
Department of Animal Biochemistry, College of Biology, China Agricultural University, Beijing, China
FIELDS OF INTEREST
- Stem cell biology and medical application.
- Embryonic cloning and transgenic animal.
MEMBERSHIP
Chinese Agricultural Biotechnology Association (2006-)
International Society of Stem Cell Research (2006-)
Sino-American Pharmaceutical Professionals Association (SAPA), USA (2003-)
Canadian Society for Cellular and Molecular Biology (1993-1997)
The Biochemical Society (London, UK. 1988-1992)
TEACHING
Advanced Biochemistry, 60 hours
Gene Chip Technology, 40 hours
Animal Biotechnology, 40 hours
PUBLICATIONS (selected)
Junhe Hu, Jianchang Bao, Xiaoling Ma, Wei Li, Anmin Lei, Chunrong Yang, Zhimin Gao, Huayan Wang* FSH Is Superior to eCG for Promoting Ovarian Response In Chinese Bamei Gilts. Animal reproduction Sciences 2010 (in press)
Junhe Hu, Xiaolin Ma, Jian Chang Bao, Li Wei, De Chen, Zhimin Gao, Anmin Lei, Chunrong Yang, Huayan Wang* Insulin–tranferrin–selenium (ITS) Improves Porcine Oocyte Maturation In Vitro. Zygote 2010 (in press).
Renjith Mathew, Wenwen Jia, Arati Sharma, Yuanjun Zhao, Loren E. Clarke, Xiang Cheng, Huayan Wang, Ugur Salli, Kent E. Vrana, Gavin P. Robertson, Jiyue Zhu, and Shuwen Wang. Robust activation of the human but not mouse telomerase gene during the induction of pluripotency. The FASEB Journal. article fj.09-148973. Published online March 30, 2010.
Xiuju Li, Lei Lei, Huayan Wang, L. Fliegel*. The Na+/H+ Exchanger Isoform 1 Facilitates Cardiomyocyte Embryonic Stem Cell Differentiation. Am. J. Physiol. –Heart Circ Physiol.2009; 296: H159-H170.
Lei Qu, Xueyi Yang, Xin Wang, Ming Zhao, Shengli Mi, Zhongying Dou, Huayan Wang*. Reconstruction of corneal epithelium with cryopreserved corneal limbal stem cells in a rabbit model. The Veterinary Journal. 2009， 179：392-400
Wang Han, Dou Zhong-Ying, Wang Hua-Yan*. Growth and identification of human amniotic fluid stem cells and analysis of their influencing factors. Chinese Journal of Agricultural Biotechnology 2009, 6(2); 1–5
Lei Lei, Lin Dou, Huayan Wang*. Knock-down Nanog gene expression by siRNA affects the differentiation of cardiomyocytes in P19 cell。Cell Research 2008, 18: s36
Wenwen Jia, Weifeng Yang, Anmin Lei, Zhimin Gao, Chunrong Yang, Jinlian Hua, Weiwei Huang, Xiaoling Ma, Huayan Wang*. A caprine chimera produced by injection of embryonic germ cells into a blastocyst. Theriogenology 2008 Vol 69 (3) 340-348 SCI 1.911
Xinkang Wang*, Giora Feuerstein, Lin Xu, Huayan Wang, William Schumacher, Martin Ogletree, Rebecca Taub, James Duan, Carl Decicco, and Rui-Qin Liu. Inhibition of tumor necrosis factor--converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats. Mol. Pharmacol. 65:890-896 (2004)
Xinkang Wang, Lin Xu, Huayan Wang, Reinhard Grzanna, Yutian Zhan, Robert Knabb, Joseph Luettgen, Tracy Bozarth, Robert Galemmo, Pancras Wong, Roberta Bernard, Hugo Vargas, Michael Chopp, Steve Friedman, and Giora Feuerstein. Inhibition of factor Xa reduces ischemic brain damage after thromboembolic stroke in rats. Stroke 34: 467-474 (2003)
Xinkang Wang, Lin Xu, Huayan Wang, Peter Young, Mathias Gasetel, and Giora Feuerstein. Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice. J. Biol. Chem. 277: 43968-43972 (2002)
Xinkang Wang, Lin Xu, Huayan Wang, Yutian Zhan, Ellen Pure, and Giora Feuerstein. CD44 deficiency in mice protects brain from cerebral ischemia injury. J. Neurochem. 83: 1172-1179 (2002)
Huayan Wang, Lin Xu, Sivakami Venkatachalam, James M. Trzaskos, Steven M. Friedman, Giora Z. Feuerstein and Xinkang Wang. Differential Regulation of IL-1and TNF- RNA expression by MEK1 inhibitor after focal cerebral ischemia (FCI) in mice. BBRC 286, 869-874 (2001)
Huayan Wang, Yutian Zhan, Lin Xu, Giora Z. Feuerstein, and Xinkang Wang. Use of suppression subtractive hybridization for differential gene expression in stroke: discovery of CD44 gene expression and localization in permanent focal stroke in rats. Stroke, 32(4): 1021-1027 (2001)
Wang, H. D. Singh and L. Fliegel. Functional role of cysteine residues in the Na+/H+ exchanger: effects of mutation of cysteine residues on targeting and activity of the Na+/H+ exchanger. Archives Biochem. Bioph. 358: 116-124 (1998)
Wang, H. D. Singh and L. Fliegel. The Na+/H+ antiporter potentiates growth and retinoic acid induced differentiation of P19 cells. J. Biol. Chem. 272: 26545-26549 (1997)
Wang, H. and L. Fliegel. Interactions of a high mobility group like protein with human mitochondrial DNA. Archives Biochem. Bioph. 346: 193-202 (1997)
Wang H, W. Yang and L. Fliegel. Identification of an HMG-like protein involved in regulation of Na+/H+ exchanger expression. Mol. Cell. Biochem. 176:99-106 (1997)
Wang, H., N. Silva, R. Haworth, K.H. Wang, L. Fliegel. Mitogen activated protein kinase activation of the Na+/H+ exchanger. Biochemistry J. 36(30):9151-9158 (1997)
Silva, N.L., H. Wang, C.V. Harris, D. Singh and L. Fliegel. Characterization of the Na+/H+ exchanger in human choriocarcinoma (BeWo) cells. European. J. Physiol. 433: 792-802 (1997)
Yang, W., H. Wang and L. Fliegel. Regulation of Na+/H+ exchanger gene expression: role of a novel poly (dA:dT) element in regulation of the NHE1 promoter. J. Biol. Chem. 271: 20444-20449 (1996)
Wang, H., L. Fliegel, C. Cass, A. Penn, M. Michalak, J. Weiner and B. Lemire. Zidovudine and dideoxy nucleosides deplete wild-type mitochondrial DNA levels and increase deleted mitochondrial DNA levels in cultured Kearns-Sayre syndrome fibroblasts. Biochem. Bioph. Acta Vol. 1316: 51-59 (1996)
Yang, W., J.R.B. Dyck, H. Wang and L. Fliegel. Regulation of the NHE-1 promoter in the mammalian myocardium.
Am. J. Physiol. 39: H259-H266 (1996)
Wang, H., L. Fliegel, C. Cass, A. Penn, M. Michalak, J. Weiner and B. Lemire. A HMG-like protein interaction with mutant human mitochondrial genome. Biochem. Cell Biol. 74: 610-611 (1996)
Wang, H., L. Fliegel, C. Cass, A. Penn, M. Michalak, J. Weiner and B. Lemire. Quantification of mitochondrial DNA in heteroplasmic skin fibroblasts with competitive PCR. Biotechniques 17: 76-82 (1994)
Fliegel, L., J. Dyck, H. Wang, C. Fong and R. Haworth. Cloning and analysis of the human myocardial Na+/H+ exchanger. Mol. Cell. Biochem. 125: 137-143 (1993)
Wang, H., D. O'Mahony, D. McConnell and S.Qi. Optimization of the synthesis of porcine somatotropin in E. coli.
Applied Microbiology & Biotechnology 39:324-328 (1993).
Wang, H. and B. Dowds. Phase variation in Xenorhabdus luminescens: cloning and sequencing of the lipase gene and analysis of its expression in primary and secondary phases of the bacterium. Journal of Bacteriology 175: 1665-1673 (1993).