DENG wen
DENG Wen, Ph.D., Professor.
Born in Hanzhong City, Shaanxi, China.
Contact
Address: Xinong Road 22, College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China
Email: w.deng@nwafu.edu.cn
Fax: +86-(0)29-8709-1032
1. Education and Work Experiences:
Dec. 2020 – now, Professor, College of Veterinary Medicine, Northwest A&F University (NWAFU), China
Jul. 2017 – Sep. 2020, Scientific Researcher, Faculty of Biology, Ludwig Maximilian University of Munich (LMU Munich), Germany
Feb. 2014 – Jul. 2017, Postdoc, Faculty of Biology, LMU Munich, Germany
Sep. 2008 – Jan. 2014, Ph.D. (Dr. rer. nat.), Human Biology, Faculty of Biology, LMU Munich, Germany
Sep. 2005 – Jul. 2008, Master, Preventive Veterinary Medicine, College of Veterinary Medicine, NWAFU (Bachelor-Master program)
Sep. 2002 – Jul. 2006, Bachelor, Biotechnology, College of Life Sciences, NWAFU, China (Bachelor-Master program)
2. Teaching and Research
Major research interests:
Host-cell interactions of veterinary and zoonotic pathogens; characterization of pathogenic microbes in animal-derived foods; new technology development for basic and apply sciences, synthetic and chemical biology for virus researches.
Teaching:
Animal-derived Food Hygiene, Veterinary Public Heath for bachelor students, Research Ethics and Scientific Writing for master students, and Advanced Veterinary Molecular Microbiology for doctoral students.
3. Publications
Selected Publications
[1] Deng W, Bates JA, Wei H, Bartoschek MD, Conradt B and Leonhardt H. Tunable light and drug induced depletion of target proteins. Nature Communications , 11, 304 (2020).
[2] Zhang LX, Lin JH, Weng MY, Wen Y, Zhang YM* and Deng W*. RPLP1, an NS4B-interacting protein, enhances production of CSFV through promoting translation of viral genome, Virulence, 13(1): 370-386 (2022)
[3] Herce HD#, Deng W#, Helma J, Leonhardt H and Cardoso MC. Visualization and targeted disruption of protein interactions in living cells. Nature Communications , 4, 2660 (2013)
[4] Dambacher S#, Deng W#, Hahn M, Sadic D, Fröhlich J, Nuber A, Hoischen C, Diekmann S, Leonhardt H and Schotta G. CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin. Nucleus , 3, 101-110 (2012)
[5] Ren W, Gao LL, Mou YL, Deng W*, Hua JL and Yang F*. DUX: One Transcription Factor Controls 2-Cell-like Fate. International Journal of Molecular Sciences , 23(4), 2067 (2022)
Other publications:
[1] Wang T, Zhang L, Liang WL, Liu SC, Deng W, Liu YR, Liu Y, Song MZ, Guo KK and Zhang YM. Extracellular vesicles originating from autophagy mediate an antibody-resistant spread of classical swine fever virus in cell culture. Autophagy , 18:6, 1433-1449 (2022)
[2] Duan NJ, Arroyo M, Deng W, Cardoso M and Leonhardt H. Visualization and characterization of RNA–protein interactions in living cells. Nucleic Acids Research , 49(18), e107 (2021)
[3] Lei J, Ma-Lauer Y, Han YZ, Thoms M, Buschauer R, Jores J, Thiel V, Beckmann R, Deng W, Leonhardt H, Hilgenfeld R and von Brunn A. The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation. EMBO Journal , 40, e102277 (2021)
[4] Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y and Defossez PA. Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation. Molecular Cell , 67, 550-565 (2017)
[5] Borgel J, Tyl M, Schiller K, Pusztai Z, Dooley CM, Deng W, Wooding C, White RJ, Warnecke T, Leonhardt H, Busch-Nentwich EM and Bartke T. KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. Nucleic Acids Research , 45, 1114-1129 (2017)
[6] Ma-Lauer Y, Carbajo-Lozoya J, Hein MY, Müller MA, Deng W, Lei J, Meyer B, Kusov Y, von Brunn B, Bairad DR, Hünten S, Drosten C, Hermeking H, Leonhardt H, Mann M, Hilgenfeld R and von Brunn A. p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1. Proceedings of the National Academy of Sciences of the United States of America , 113, E5192-5201 (2016)
[7] Chiu HY, Deng W, Engelke H, Helma J, Leonhardt H and Bein T. Intracellular chromobody delivery by mesoporous silica nanoparticles for antigen targeting and visualization in real time. Scientific Reports ., 2016 May 13, 6, 25019 (2016)
[8] Abendroth C, Hofmeister A, Hake SB, Kamweru PK, Miess E, Dornblut C, Küffner I, Deng W, Leonhardt H, Orthaus S, Hoischen C and Diekmann S. The CENP-T C-Terminus Is Exclusively Proximal to H3.1 and not to H3.2 or H3.3. International Journal of Molecular Sciences , 16, 5839-5863 (2015)
[9] Dornblut C, Quinn N, Monajambashi S, Prendergast L, van Vuuren C, Münch S, Deng W, Leonhardt H, Cardoso MC, Hoischen C, Diekmann S and Sullivan KF. A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle. Open Biology , 4, 130229 (2014)
[10] Liu N, Wang M, Deng W, Schmidt CS, Qin W, Leonhardt H and Spada F. Intrinsic and Extrinsic Connections of Tet3 Dioxygenase with CXXC Zinc Finger Modules. PLoS One , 2013 May 14, 8, e62755 (2013)
[11] Gross H, Hennard C, Masouris I, Cassel C, Barth S, Stober-Grässer U, Mamiani A, Moritz B, Ostareck D, Ostareck-Lederer A, Neuenkirchen N, Fischer U, Deng W, Leonhardt H, Noessner E, Kremmer E and Grässer FA. Binding of the Heterogeneous Ribonucleoprotein K (hnRNP K) to the Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) Enhances Viral LMP2A Expression. PLoS One , 7, e42106 (2012)
[12] Eskat A#, Deng W#, Hofmeister A, Rudolphi S, Emmerth S, Hellwig D, Ulbricht T, Döring V, Bancroft JM, McAinsh AD, Cardoso MC, Meraldi P, Hoischen C, Leonhardt H and Diekmann S (2012). Step-Wise Assembly, Maturation and Dynamic Behavior of the Human CENP-P/O/R/Q/U Kinetochore Sub-Complex. PLoS One , 7, e44717. (2012)
[13] Dai C, Zhang YM, Zhang Q, Wu ZS, Deng W, Zhang X, Guo KK, Tang QH, Hou B. A MicroRNA Catalog of Swine Umbilical Vein Endothelial Cells Identified by Deep Sequencing. Agricultural Sciences in China , 10, 1467-1474 (2011)
4. Projects and Funding
[1] Shaanxi Basic Research Plan for Natural Sciences, 2022JM-104, 2022 - 2023, grant holder & lead researcher.
[2] Funding for Young Talents in NWAFU, 1 million RMB Yuan, 2021 - 2025, grant holder & lead researcher.
[3] Cooperation project, Bavarian Research Foundation, 2018.04 - 2020.03, participant.