LI qinfan
LI Qinfan
Ph. D., Professor.
Email: liqf1131@163.com
Department of Clinical Veterinary Medicine,
College of Veterinary Medicine,
Northwest A&F University,
No.3 Taicheng Road, Yangling, Shaanxi, China, 712100
Education:
1/9/1987-1/7/1992 B.S. in Veterinary Medicine, Northwest Agricultural University, Shaanxi, China
1/9/2002-1/7/2005 M.S. in Clinical Veterinary Science, Northwest A&F University, Shaanxi, China
1/9/2001-1/72005 Ph.D. in Clinical Veterinary Science, Northwest A&F University, Shaanxi, China
1/10/2006-1/10/2007 Visiting Institute for Medical Chemistry, DNS, University for Veterinary Medicine, Vienna, Austria
Area of Research:
Animal disease and Toxicology, focuses on the structure and function of Capra hircus lysosoma α-mannosidase ( ch LAM) and Capra hircus golgi α-mannosidaseⅡ ( ch GMII), including cloning and expressing the gene, studying the character, determining active center and building the 3D structure of ch LAM and ch GMII. Elucidate the molecular mechanism about SW inhibits α-mannosidase.
Research Grants
1/2019-12/2022 The replacement of domain binding swainsonine and its functional verification in Capra hircus lysosomal α-mannosidase, National Nature Science Foundation of China (No. 31860724)
1/2017-12/2019 Research and demonstration of key technologies for prevention and control of mastitis and endometritis, Key R & D projects of Shaanxi Province-agricultural field, China (No. 2017ZDXM-NY-079
1/2014-12/2016 The development and application of the enzyme preparation of swainsonine poisoning in sheep, Shaanxi science and technology project, China (No. 2014K01-17-02)
1/2008-12/2010 Degradation of toxic alkaloid TMPD from Oxytropis glacialis by bacteria, Shaanxi science and technology project, China (No. 2008K02-06)
Selected Publications (†indicates contributed equally, *indicates corresponding author)
[1] Li Qinfan, Wang Yingzi, Rudolf Moldzio, Lin Weimin, Wolf-Dieter Rausch*. Swainsonine as a lysosomal toxin affects dopaminergic neurons,Journal of Neural Transmission,2012,119: 1483-1490.
[2] Li Qinfan†, Zhang Lihui†, Ma Zhi, Kong Xiangya, Wang Fangfang, Zhang Hong, Wang Yonghua*. Probing structural features and binding mode of 3-Arylpyrimidin-2,4-diones within housefly γ-Aminobutyric acid (GABA) receptor. International Journal of Molecular Sciences,2011,12(9): 6293-63111.
[3] Li Qinfan†, Kong Xiangya†, Xiao Zhengtao, Zhang Lihui, Wang Fangfang, Zhang Hong, Li Yan, Wang Yonghua*. Structural determinants of imidacloprid-based nicotinic acetylcholine receptor inhibitors identified using 3D-QSAR,docking and molecular dynamics, J Mol Model. 2012, 18: 2279–2289.
[4] Li Qinfan, Hao Caiju, Xu Yongping, Liang Jie, Yang Kai, Cui Zhonghua. Identification of a new Locoweed ( Oxytropis serioopetala ) and its clinical and pathological features in poisoned rabbits. J Vet Med Sci,2012,8:989-993.
[5] Li Qinfan†, Fang Yupeng†, Li Xiuxiu, Zhang Hong, Liu Mengmeng, Yang Huibin, Kang Zhuo, Li Yan, Wang Yonghua*. Mechanism of the plant cytochrome P450 for herbicide resistance: a modelling study,Journal of Enzyme Inhibition and Medicinal Chemistry, 2013,28(6):1182-1191.
[6] Kong Xiangya, Zhang Jiangye, Wu Ying, Li Jianfei,Li Qinfan*. Molecular characterization of Capra hircus lysosomal α-mannosidase and potential mutant site for the therapy of locoweed poisoning,Acta Biochim Pol. 2014, 61(1): 77-84.
[7] Li Jianfei, Zhang Jiangye, Lai Bi, Zhao Ying, Li Qinfan*. Cloning, expression, and characterization of Capra hircus Golgi α-Mannosidase II. Appl Biochem Biotechnol, 2015, 177(6): 1241-1251.
[8] Yang Kai, Liang Jie, Li Qinfan*, Kong Xiangya, Chen Rui, Jin Yimin. Cladosporium cladosporioides XJ-AC03, an aconitine-producing endophytic fungus isolated from Aconitum leucostomum . World Journal of Microbiology and Biotechnology. 2013, 29: 933–938 .
[9] Liu Xiaoqiang, Liu Haixia, Wang Le, Peng Qian, Li Yinqian, Zhou Hongchao, Li Qinfan*. Molecular characterization of extended-spectrum β-lactamase- producing multidrug resistant Escherichia coli from swine in northwest China. Front Microbiol. 2018, 9:1756.doi:10. 3389
[10] Wang Yan, Zhai A’guan, Zhang Yanqi, Qiu Kai, Wang Jianhua, Li Qinfan*. by Swainsonine of Degradation the NADP-Dependent Alcohol Dehydrogenase A1R6C3 in Arthrobacter sp.HW08. Toxins, 2016, 8(5): 145.
[11] Xu Xingang†, Xu Ying†, Zhang Qi, Yang Feng, Yin Zheng, Wang Lixiang, Li Qinfan*. Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)/p53, but not p38 MAPK and SAPK/JNK signalling pathways. Vet Microbiol. 2019 May; 232:1-12. doi: 10.1016/j.vetmic.2019.03.028. Epub 2019 Mar 30.
Awards
The Second Prize of Shaanxi Science and Technology Progress Award (R2), 2007, Shaanxi Provincial Government, China.