中文版

ZHAO qin

ZHAO Qin赵钦教授.jpg

Ph.D., Professor

Born in Apr.1982, Lai’yang City, Shandong, China

Contact

Address: College of Veterinary Medicine, Northwest A&F University

No. 22 Xinong Road, Yangling, 712100, Shaanxi, China.

Email(s): qinzhao_2004@nwafu.edu.cn, qinzhao_2004@sina.com

Mobile: +86 18792650493

Telephone: +86-(0)29-8709-9086

1. Education and Work Experience

01.2021 – now, Professor, College of Veterinary Medicine, Northwest A&F University

01.2015 – 12.2020, Associate Professor, College of Veterinary Medicine, Northwest A&F University

07.2011 – 12.2014, Assistant Professor, College of Veterinary Medicine, Northwest A&F University

09.2008 – 06.2011, Ph.D., Preventive Veterinary Medicine, College of Animal science and Veterinary Medicine, Shandong Agriculture University

09.2005 – 07.2008, Master, Preventive Veterinary Medicine, College of Animal science and Veterinary Medicine, Shandong Agriculture University

09.2000 – 07.2004, Bachelor, Veterinary Medicine, College of Animal science and Veterinary Medicine, Shandong Agriculture University

2. Research and Teaching

Research interests:

Mechanism of animal infectious diseases, such as HEV and PRRSV infection.

Research of new vaccine, diagnostic kits and antiviral drug of animal diseases.

Prevention and control of epidemic disease in pig, such as  ASF and PRRS disease.

Teaching:

Veterinary Immunology for bachelor students.

Advanced Veterinary Immunology for master students.

Veterinary Biological for doctoral students.

3. Memberships and Academic Services

Member of the Council of Avian Disease and Animal Infection Disease of Chinese Association of Animal Science and Veterinary Medicine

Member of the Chinese Association of Immunology

Member of the Chinese Association of Microbiology

Associate editor in Virology of Journal “Frontiers in Microbiology”

4. Honors and Awards

Tang Scholar of Cyrus Tang Foundation（2017-2019）

National Science Fund of Shaanxi Province for Distinguished Young Scholar（2022-2024）

5. Publications

[1] Yani Sun, Wenlong Yan, Xu Chen, Qianqian Liu, Pinpin Ji, Jiahong Zhu, Lili Gai, Xiaoxuan Li, Jiakai Zhao, Lu Zhang, Hao Zhang, Baoyuan Liu, En-Min Zhou, Qin Zhao*. Antigenic cross-reactivity among human, swine, rabbit and avian hepatitis E virus capsid proteins. Vet Microbiol. 2022, 265: 109331.

[2] Mengnan Fan, Yuhang Luo, Beibei Zhang, Jiaxi Wang, Tianxiang Chen, Baoyuan Liu, Yani Sun, Yuchen Nan, Julian A. Hiscox, Qin Zhao*, En-Min Zhou*. Cell Division Control Protein 42 Interacts With Hepatitis E Virus Capsid Protein and Participates in Hepatitis E Virus Infection. Front Microbiol. 2021, 775083.

[3] Hong Duan, Xu Chen, Jiakai Zhao, Jiahong Zhu, Guixi Zhang, Mengnan Fan, Beibei Zhang, Xueting Wang, Yani Sun, Baoyuan Liu, En-Min Zhou*, Qin Zhao*. Development of a nanobody-based competitive ELISA for efficiently and specifically detecting antibodies against genotype 2 porcine reproductive and respiratory syndrome viruses. J Clin Microbiol. 2021, Nov 18; 59(12): e0158021.

[4] Lu Zhang#, Lizhen Wang#, Shuaishuai Cao, Huanhuan Lv, Jingjing Huang, Guixi Zhang, Kaissar Tabynov, Qin Zhao* and En‑Min Zhou*. Nanobody Nb6 fused with porcine IgG Fc as the delivering tag to inhibit porcine reproductive and respiratory syndrome virus replication in porcine alveolar macrophages. Veterinary Research. 2021, 52:25.

[5] Xuan Dong, Tao Hu, Qingyuan Liu, Chen Li, Yani Sun, Yiting Wang, Weifeng Shi*, Qin Zhao*, and Jie Huang*. A Novel Hepe-Like Virus from Farmed Giant Freshwater Prawn Macrobrachium rosenbergii. Viruses. 2020, 12, 323.

[6] Pinpin Ji, Jiahong Zhu, Xiaoxuan Li, Wenqi Fan, Qianqian Liu, Kun Wang, Jiakai Zhao, Yani Sun, Baoyuan Liu, En‑Min Zhou* and Qin Zhao*. Fenobody and RANbody‑based sandwich enzyme‑linked immunosorbent assay to detect Newcastle disease virus. J Nanobiotechnol. 2020, 18:44.

[7] Yani Sun#, Qizhong Lu#, Jingfei Zhang, Xiaoxuan Li, Jiakai Zhao, Wenqi Fan, Pinpin Ji, Kun Wang, En-Min Zhou*, Qin Zhao*. Co-infection with Avian Hepatitis E Virus and Avian Leukosis Virus Subgroup J as the Cause of an Outbreak of Hepatitis and Liver Hemorrhagic Syndromes in a Brown Layer Chicken Flock in China. Poult Sci. 2020, 99 (3), 1287-1296.

[8] Xinjie Wang#, Pinpin Ji#, Huiying Fan#, Lu Dang#, Wenwei Wan, Siyuan Liu, Yanhua Li, Wenxia Yu, Xiangyang Li, Xiaodong Ma, Xu Ma, Qin Zhao*, Xingxu Huang*, Ming Liao* . CRISPR/Cas12a technology combined with immunochromatographic strips for portable detection of African swine fever virus. Communications Biology. 2020, 3: 62.

[9] Qizhong Lu#, Xiaoxuan Li#, Jiakai Zhao, Jiahong Zhu, Yuhang Luo, Hong Duan, Pinpin Ji, Kun Wang, Baoyuan Liu, Xueting Wang, Wenqi Fan, Yani Sun, En‑Min Zhou* and Qin Zhao*. Nanobody‑horseradish peroxidase and ‑EGFP fusions as reagents to detect porcine parvovirus in the immunoassays. J Nanobiotechnol. 2020, 18:7.

[10] Peng Sun, Shaoli Lin, Shenghu He*, En-Min Zhou* and Qin Zhao*. Avian Hepatitis E Virus: With the Trend of Genotypes and Host Expansion. Frontiers in Microbiol. 2019, 10:1696.

[11] Huixia Li, Mengnan Fan, Baoyuan Liu, Pinpin Ji, Yiyang Chen, Beibei Zhang, Yani Sun, Baicheng Huang, Yuchen Nan, Zhenzhao Sun, James P. Stewart, Julian A. Hiscox, Qin Zhao*, En-Min Zhou*. Chicken organic anion transporting polypeptide 1A2, a novel avian hepatitis E virus (HEV) ORF2-interacting protein, is involved in avian HEV infection. J Virol. 2019, 93(11), pii: e02205-18.

[12] Yamin Sheng#, Kun Wang#, Qizhong Lu, Pinpin Ji, Baoyuan Liu, Jiahong Zhu, Qingyuan Liu, Yani Sun, Jingfei Zhang, En‑Min Zhou*，Qin Zhao*. Nanobody‑horseradish peroxidase fusion protein as an ultrasensitive probe to detect antibodies against Newcastle disease virus in the immunoassay. J Nanobiotechnol. 2019, 17:35.

[13] Baoyuan Liu#, Yiyang Chen#, Yani Sun, Yuchen Nan, Huixia Li, Taofeng Du, Julian A. Hiscox, Qin Zhao*, En-Min Zhou*. Experimental infection of rabbit with swine-derived hepatitis E virus genotype 4. Vet Microbiol. 2019, 229:168-175.

[14] Yani Sun#, Qizhong Lu, Baoyuan Liu, Yamin Sheng, Taofeng Du, Julian A. Hiscox, En-Min Zhou*, Qin Zhao*. Cross-species infection of mice by rabbit hepatitis E virus, Vet Microbiol, 2018, 225: 48-52.

[15] Huixia Li, Junyuan Wu, Yamin Sheng, Qizhong Lu, Baoyuan Liu, Yiyang Chen, Yani Sun, En-Min Zhou*, Qin Zhao*. Prevalence of hepatitis E virus (HEV) infection in various pig farms from Shaanxi Province, China: First detection of HEV RNA in pig semen. Transbound Emerg Dis. 2019, 66(1):72-82.

[16] Yiyang Chen, Baoyuan Liu, Yani Sun, Huixia Li, Taofeng Du, Yuchen Nan, Julian A. Hiscox, En-Min Zhou*, Qin Zhao*. Characterization of Three Novel Linear Neutralizing B-Cell Epitopes in the Capsid Protein of Swine Hepatitis E Virus. J Virol. 2018, 92(13), pii: e00251-18.

[17] Baoyuan Liu, Mengnan Fan, Beibei Zhang, Yiyang Chen, Yani Sun, Taofeng Du, Yuchen Nan, En-Min Zhou* and Qin Zhao*. Avian hepatitis E virus infection of duck, goose, and rabbit in northwest China. Emerging Microbes & Infections. 2018, 7(1):76.

[18] Baoyuan Liu, Yani Sun (Co-first author), Yiyang Chen, Taofeng Du, Yuchen Nan, Xinjie Wang, Huixia Li, Baicheng Huang, Gaiping Zhang, En-Min Zhou*, Qin Zhao*. Effect of housing arrangement on fecal-oral transmission of avian hepatitis E virus in chicken flocks. BMC Vet Res, 2017, 13:282.

[19] Shahid Faraz Syed, Yani Sun (Co-first author), Taofeng Du, Yiyang Chen, Baoyuan Liu, Xinjie Wang, Huixia Li, Yuchen Nan, En-Min Zhou*, Qin Zhao*. Evaluation of recombinant Chinese avian hepatitis E virus (CaHEV) ORF2 and ORF3 proteins for protection of chickens against CaHEV infection. Vaccine, 2017, 35, 3482-3489.

[20] Qin Zhao, Baoyuan Liu, Yani Sun, Taofeng Du, Yiyang Chen, Xinjie Wang, Huixia Li, Yuchen Nan, Gaiping Zhang, En-Min Zhou*. Decreased egg production in laying hens associated with infection with genotype 3 avian hepatitis E virus strain from China. Vet Microbiol. 2017, 203, 174-180.

[21] Baoyuan Liu, Yani Sun, Taofeng Du, Yiyang Chen, Xinjie Wang, Baicheng Huang, Huixia Li, Yuchen Nan, Shuqi Xiao, Gaiping Zhang, Julian A. Hiscox, En-Min Zhou*, Qin Zhao*. Rabbit hepatitis E virus is an opportunistic pathogen in specific-pathogen-free rabbits with the capability of cross-species transmission. Vet Microbiol, 2017, 201, 72-77.

[22] Yani Sun, Taofeng Du, Baoyuan Liu, Shahid Faraz Syed, Yiyang Chen, Huixia Li, Xinjie Wang, Gaiping Zhang, En-Min Zhou*, Qin Zhao*. Seroprevalence of avian hepatitis E virus and avian leucosis virus subgroup J in chicken flocks with hepatitis syndrome, China. BMC Vet Res. 2016, 12 (1): 261.

[23] Yiyang Chen, Qin Zhao (Co-first author), Baoyuan Liu, Lizhen Wang, Yani Sun, Huixia Li, Xinjie Wang, Shahid Faraz Syed, Gaiping Zhang, En-Min Zhou*. A Novel Blocking ELISA for Detection of Antibodies against Hepatitis E Virus in Domestic Pigs. PLoS ONE. 2016, 11 (3): e0152639.

[24] Qin Zhao, Shahid Faraz Syed, En-Min Zhou*. Antigenic properties of avian hepatitis E virus capsid protein. Vet Microbiol. 2015, 180 (1-2): 10-14.

[25] Qin Zhao, Sha Xie, Yani Sun, Yiyang Chen, Jiming Gao, Huiya Li, Xinjie Wang, Shahid Faraz Syed, Baoyuan Liu, Lizhen Wang, Gaiping Zhang, En-Min Zhou*. Development and evaluation of a SYBR Green real-time RT-PCR assay for detection of avian hepatitis E virus. BMC Vet Res. 2015, 11(1): 195-202.

[26] Xinjie Wang, Qin Zhao (Co-first author), Lu Dang, Yani Sun, Jiming Gao, Baoyuan Liu, Shahid Faraz Syed, Hu Tao, Gaiping Zhang, Jianxun Luo, and En-Min Zhou*. Characterization of two novel linear B-cell epitopes in the capsid protein of avian hepatitis E virus (HEV) that are common to avian, swine, and human HEVs. J Virol. 2015, 89(10):5491-5501.

[27] Lizhen Wang, Yani Sun, Taofeng Du, Chengbao Wang, Shuqi Xiao, Yang Mu, Gaiping Zhang, Lihong Liu, Frederik Widén, Walter H. Hsu, Qin Zhao* and En-Min Zhou*. Identification of an antigenic domain in the N-terminal region of avian hepatitis E virus (HEV) capsid protein that is not common to swine and human HEVs. J Gen Virol. 2014, 95: 2710-2715.

[28] Qin Zhao, Yani Sun, Gaiping Zhang, Frederik Widén, En-Min Zhou*. Antigenic domains of avian HEV: bases for serological diagnosis of HEV in avian, swine and human. British J Virol. 2014, 1 (3): 103-105.

[29] Xinjie Wang, Qin Zhao (Co-first author), Fenglin Jiang, Baoyuan Liu, Jinan Zhao, Lu Dang, Yani Sun, Yang Mu, Shuqi Xiao, Chengbao Wang, Walter H. Hsu, Lihong Liu, Frederik Widén, En-Min Zhou*. Genetic characterization and serological prevalence of swine hepatitis E virus in Shandong province, China. Vet Microbiol. 2014, 172: 415–424.

[30] Qin Zhao, Yani Sun, Shoubin Hu, Xinjie Wang, Yihong Xiao, Walter H. Hsu, Shuqi Xiao, Chengbao Wang, Yang Mu, Julian A. Hiscox, En-Min Zhou*. Characterization of antigenic domains and epitopes in the ORF3 protein of a Chinese isolate of avian hepatitis E virus. Vet Microbiol. 2013, 167: 242–249.

[31] Qin Zhao, Yani Sun, Jinan Zhao, Shoubin Hu, Feifei Zhao, Fuyong Chen, Alfonso Clavijo, En-Min Zhou*, Yihong Xiao*. Development and application of an indirect ELISA to detect antibodies against avian hepatitis E virus. J Virological Methods. 2013, 187: 32-36.

[32] Dong SW, Qin Zhao (Co-first author), Lu MZ, Sun PM, Qiu HK, Zhang L, Lv JH, Zhou E-M*. Analysis of epitopes in the capsid protein of avian hepatitis E virus by using monoclonal antibodies. J Virol Methods, 2011, 171 (2): 374-380. (IF: 2.133)

[33] Qin Zhao, Zhou E-M*, Dong SW, Qiu HK, Zhang L, Hu SB, Zhao FF, Jiang SJ, Sun YN. Analysis of Avian Hepatitis E Virus from Chickens, China. EID, 2010, 16 (9): 1469-1472.

Books:

[1]  China Poultry Diseases . Chapter 4, 155-159, Chinese Agriculture Press (2016).

6. Projects and Funding

[1] General Project, No. 31972676, National Natural Science Foundation of China (NSFC), 580,000 RMB Yuan, 2020 - 2023, grant holder.

[2] General Project, No. 31672583, National Natural Science Foundation of China (NSFC), 620,000 RMB Yuan, 2017 - 2020, grant holder.

[3] Distinguished Young Scholar, No. 2022JC-12, Natural Science Foundation of Shaanxi Province. 500,000 RMB Yuan, 2022 - 2024, grant holder。

[4] Young Project, No. 31402233, National Natural Science Foundation of China (NSFC), 240,000 RMB Yuan, 2015 - 2027, grant holder.

[5] Key project, No. 2016YFD0500801, National Key R&D Program of China, 940,000 RMB Yuan, 2016-2021, grant holder.

[6] International cooperation project, No. 31720103919, National Natural Science Foundation of China (NSFC), 2,400,000 RMB Yuan, 20118-2022, participant.