WANG yongsheng
WANG Yongsheng
Ph.D., Professor
Born in October.1977, Shaoyang City, Hunnan, China
Contact
Address: College of Veterinary Medicine, Northwest A&F University
No. 22 Xinong Road, Yangling, 712100, Shaanxi, China.
Email(s): wangyongsheng01@nwsuaf.edu.cn
Mobile: +86 15353711236
Telephone: +86-(0)29-87080092
Fax: +86-(0)29-8709-80085
1. Education and Work Experience
01.2019 – now, Professor, College of Veterinary Medicine, Northwest A&F University
04.2012 – 12.2018, Associate Professor, College of Veterinary Medicine, Northwest A&F University
07.2009 – 04.2012, Postdoctoral training, College of Veterinary Medicine, Northwest A&F University
09.2004 – 07.2009 Ph.D., Clinical Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University
09.2001– 07.2004, Master, Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University
09.1997 – 07.2001, Bachelor, Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University
2. Research and Teaching
Research interests:
Molecular mechanism of early embryo development;
Cultivation of disease resistant transgenic cattle;
In vitro fertilization and somatic cloning.
Teaching:
Animal Tissue and Embryology for bachelor students.
Animal Anatomy and Histoembryology for bachelor students.
Cell and Embryo Engineering for master students.
Animal Cloning and Transgenic for doctoral students.
3. Memberships and Academic Services
Science and technology consulting expert of Lingwu City, Ningxia Hui Autonomous Region.
Science and technology consulting expert of Changwu county, Xianyang city, Shaanxi Province.
4. Honors and Awards
(1) Efficient cloning technology of cattle and sheep, Second prize of national science and technology invention, 2016 (5/6);
(2) Research and application of cattle and sheep accurate gene editing technology ，The first prize of Shaanxi Provincial Science and Technology Progress Award, 2015 (4/12);
(3) Research and application of key technologies for cattle and sheep breeding, The first prize of Shaanxi Provincial Science and Technology Progress Award, 2013 (2/13)
5. Publications
（1） Mengyun Wang, Yue du, Pengxiang Qu, Yang Gao, Jingyi Wang, Zhengqing Liu, Yong Zhang*, Suzhu Qing*,Yongsheng Wang*. Sperm-borne miR-202 targets SEPT7 and regulates first cleavage of bovine embryos via cytoskeletal remodeling. Development, 2021, 148(5).
（2）Yuanpeng Gao#, Haibo Wu#, Yongsheng Wang#, Xin Liu, Linlin Chen, Qian Li, Chenchen Cui, Xu Liu, Jingcheng Zhang, Yong Zhang*.Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off target effects. Genome Biology. 2017, 18:13.
（3）Haibo Wu, Wang Yongsheng, Yan Zhang, Mingqi Yang, Jiaxing Lv, Jun Liu, and Yong Zhang. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. PNAS, 2015. 112(3):E1530-1539.
（4）Jingcheng Zhang, Pengxiang Qu, Chuan Zhou, Xin Liu, Xiaonan Ma, Mengyun Wang, Jianmin Su, Jun Liu, Yongsheng Wang*,Yong Zhang*. MicroRNA-125b is a key epigenetic regulatory factor that promotes nuclear transfer reprogramming. Journal of Biological Chemistry. 2017, 292, 15916-15926.
（5）Pengxiang Qu#, Zhenzi Zuo#, Zhengqing Liu, Zhihan Niu, Ying Zhang, Yue Du, Xiaonan Ma, Fang Qiao, Mengyun Wang, Yong Zhang*, Suzhu Qing*, Yongsheng Wang*. Sperm-borne small RNAs regulate α-tubulin acetylation and epigenetic modification of early bovine somatic cell nuclear transfer embryos. Molecular Human Reproduction. 2019, 25(8),471–482.
（6） Zhenzi Zuo, Zhihan Niu, Zhengqing Liu, Jukui Ma, Pengxiang Qu, Fang Qiao, Jianmin Su, Yong Zhang*, Yongsheng Wang*. The effects of glycine-glutamine dipeptide replaced l-glutamine on bovine parthenogenetic and IVF embryo development. Theriogenology, 2020,141, 82-90
(7) Xu Liu, Wang Yongsheng, Wenjiang Guo, Bohao Chang, Jun Liu, Zekun Guo, Yong Zhang. Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus in cloned cows. Nature Communications. 2013(4):1-11.
6. Projects and Funding
[1]. The mechanism of sperm-borne mir-202 regulating cytoplasmic skeleton remodeling of early bovine embryos (January 2020 to December 2023), National Natural Science Foundation of China (No. 31972572), 590,000 RMB Yuan, grant holder.
[2]. Identification and function research of sperm specific miRNAs related to embryonic development (January 2015 December 2018), National Natural Science Foundation of China (No. 31201940), 870,000 RMB Yuan, grant holder.
(3) Rapid propagation of improved dairy cattle breeds (2021-2022), Project of Ningxia Wuzhong agricultural investment company, 170,0000 RMB Yuan, grant holder.
(4) Development and application of health control technology for high-yield dairy cows in high production period (July 2021-July 2023), key R & D project of Ningxia Hui Autonomous Region, 100,0000 RMB Yuan, grant holder.
(5) Conservation and restoration of rare and endangered local pig somatic stem cell genetic resources, (2022.1-2026.12), National key research and development sub project of the 14th five year plan (No. 2021YFD200303-06), 220,0000 RMB Yuan, grant holder.