南雨辰

作者:  来源:  发布日期:2017-07-20 浏览次数:

1. 个人基本信息

南雨辰,男,1985年3月出生,甘肃天水人,美国马里兰大学兽医学院分子病毒学方向博士学位,陕西省委组织部“百人计划”入选者。 自2015年9月入职西北农林科技大学动物医学院,任博士生导师;副教授 。现任西北农林科技大学国际合作与交流处副处长,西北农林科技大学党外知识分子联谊会(知联会)秘书长,动物医学院预防兽医系副主任。目前主要从事家畜重大病毒性疫病致病机制研究,累计发表SCI论文40余篇,主持国家自然科学基金面上项目(31672534),国家十三五重点研发计划动物疫病生物防治性制剂研制与产业化专项课题(2017YFD0501004),陕西省百人计划,陕西省引进人才专项,中国科协青年人才托举计划,留学人员科技活动择优资助项目及校级引进人才科研启动经费多项。兼任国家自然科学基金面上项目及教育部“青年长江学者”通讯评审专家;科技部在库专家;江西华牧生物科技有限公司夏咸柱院士工作站专家组成员,新疆方牧生物科技有限公司首席技术顾问。

2. 教育经历

2003年-2007年:西北农林科技大学动物医学专业本科;

2007年-2009年:西北农林科技大学预防兽医学硕士(出国直博未获硕士学位);

2009年-2014年:美国马里兰大学,分子病毒学方向,博士(Ph. D.);

3. 工作经历

2014年8月-2015年9月:美国马里兰大学,博士后;

2015年9月至今:西北农林科技大学动物医学院,博士生导师;副教授;

2016年7月-2018年7月:西北农林科技大学动物医学院院长助理;

2018年12月至今:西北农林科技大学党外知识分子联谊会(知联会)秘书长;

2019年7月至今:西北农林科技大学国际合作与交流处(港澳台办)副处长;

4. 研究方向

(1)戊型肝炎病毒(HEV)与宿主细胞相互作用机理;

(2)具备干扰素诱导表型及鉴别标记的猪繁殖与呼吸综合征病毒(PRRSV)新型疫苗开发;

(3)抗PRRSV广谱中和抗体中和PRRSV感染机制及识别抗原表位的鉴定;

(4)猪重大疫病全宿主源基因工程抗体的研发;

5. 主讲课程

本科生:《免疫生物学》(全英文课程);《病毒学》(中英双语课程);

参讲博士生《兽医学专题》及硕士生《兽医免疫学》;

6.在研科研项目

(1)西北农林科技大学引进人才科研启动经费(2015.9-2019.9):戊型肝炎致病机制;100万;主持;

(2)科技部十三五国家重点研发计划“动物疫病生物防治性制剂研制与产业化项目-课题4新型治疗性动物基因工程抗体研制(课题编号:2017YFD0501004)”(2017.7-2020.12):320万;主持;

(3)国家自然科学基金面上项目(2017.1-2020.12):猪戊型肝炎病毒抑制宿主干扰素信号通路机制;61万(批准号码:31672534);主持;

(4)陕西省百人计划(2017.7-2020.12):25万;主持;

(5)陕西省人才专项经费(2017.7-2020.12):20万;主持;

7. 学术兼职

(1)美国病毒学会(American Society of Virology)正式会员

(2)国家自然科学基金生命科学八处通讯评审专家

(3)科技部在库专家,

(4)兼任下列杂志特邀审稿人( Ad hoc Reviewer )

Virology, (病毒学;SCI影响因子3.35)

American Journal of Translation Research (美国转化医学杂志;SCI影响因子3.146)

Beneficial Microbes (益生菌杂志;SCI影响因子3.301)

International Journal of Molecular Medicine (国际分子医学杂志;SCI影响因子2.348)

World Journal of Gastroenterology (世界消化医学杂志;SCI影响因子2.787)

Virus Research(病毒学研究;SCI影响因子2.87)

Virology Journal(病毒学杂志;SCI影响因子2.09)

Veterinary Microbiology, (兽医微生物学;SCI影响因子2.56)

PLoS One, (公共科学图书馆 综合;SCI影响因子3.03)

Biomedical Research International, (国际生物医学研究;SCI影响因子2.134)

Veterinary Immunology and Immunopathology, (动物免疫及免疫病理学,SCI影响因子1.9)

8. 发表论文及获得专利

(1)专利

United States Patent Granted (美国国家专利局专利号码:8906385B2): An Interferon-inducing Porcine Reproductive and Respiratory Syndrome Virus Isolate. Patent application granted. (申请日期 filed date: Dec 3, 2012, 批准日期granted date Oct 16, 2014专利生效日期Dec 9, 2014,专利保护期20年)

链接Link: http://www.google.com/patents/US20130183329

(2)代表性论文

2019年

[1].Lizhen Wang, Lu Zhang, Baichen Huang, Kuokuo Li, Gaopeng Hou, Qin Zhao, Chunyan Wu,  Yuchen Nan, Taofeng Du, Yang Mu, Jixun Lan, Hongying Chen andEn-Min Zhoua*;A Nanobody Targeting Viral Non-Structural Protein 9 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication,  Journal of Virology,  2019, (影响因子:4.6)

[2].TianshuZhai, Chunyan Wu, Nana Wang, Binjun Shi, Jie Li, Rui Chen,Jianhui Dong, YiyingZhanga, En-Min Zhouand Yuchen Nan* ;Development of a monoclonal antibody against swine leukocyte antigen(SLA)-DR α chain and evaluation of SLA-DR expression in bone marrowderiveddendritic cells after PRRSV infection,  Veterinary Immunology and Immunopathology,  2019, (影响因子:1.7通讯作者)

[3].Pengfei Li, Zixiang Zhu, Xiangle Zhang, Wen Dang, Linlin Li, Xiaoli Du,Miaotao Zhang, Chunyan Wu, QinghongXue, Xiangtao Liu, Haixue Zheng*andand Yuchen Nan* ;The Nucleoprotein and Phosphoprotein of Peste desPetits Ruminants Virus Inhibit Interferons Signalingby Blocking the JAK-STAT Pathway,  Viruses,  2019, (影响因子:3.7通讯作者)

[4].Gaopeng Hou, BiyunXue, Liangliang Li,  Yuchen Nan , Lu Zhang, Kuokuo Li, Qin Zhao,Julian Hiscox, James Stewart, Chunyan Wu*, Jingfei Wang*andEn-Min Zhou*;Direct interactionbetween CD163N-terminal domain and MYH9 C-terminaldomain contributes to porcinereproductive and respiratory syndromevirus internalization by permissive cells,  FrontiersinMicrobiology,  2019, (影响因子:4.1)

[5].JieWang, Jie Li, Nana Wang, Qi Ji, Mingshuo Li,  Yuchen Nan ,En-Min Zhou, Yanjin Zhangand Chunyan Wu*;The 40 kDa Linear Polyethylenimine Inhibits PorcineReproductive and Respiratory Syndrome VirusInfection by Blocking Its Attachment toPermissive Cells,  Viruses,  2019, (影响因子:3.7)

[6].Pengfei Li, Zixiang Zhu, Xiangle Zhang, Wen Dang, Linlin Li, Xiaoli Du,Miaotao Zhang, Chunyan Wu, QinghongXue, Xiangtao Liu, Haixue Zheng*andand Yuchen Nan* ;The 40 kDa Linear Polyethylenimine Inhibits PorcineReproductive and Respiratory Syndrome VirusInfection by Blocking Its Attachment toPermissive Cells,  Viruses,  2019, (影响因子:3.7)

[7].BiyunXue, Gaopeng Hou, Guixi Zhang, Jingjing Huang, Liangliang Li,  YuchenNan ,Yang Mu, Lizhen Wang, Lu Zhang, Ximeng Han, Xiaolei Ren, Qin Zhao, ChunyanWu * , Jingfei Wang * andEn-Min Zhou * ;MYH9 1 Aggregation Induced by Direct Interaction with PRRSV GP5 EctodomainFacilitates Viral Internalization by Permissive Cells,  FrontiersinMicrobiology,  2019, (影响因子:4.1)

2018年

[1].  Yuchen Nan,  Chunyan Wu, Qin Zhao, Yani Sun, Yan-Jin Zhang and En-Min Zhou * ; Vaccine development against zoonotic hepatitis E virus: unmet needs for public health,  Frontiers in Microbiology , 2018, (影响因子:4.32)

[2].  Yuchen Nan* ;andYan-Jin Zhang * ; Antisense PhosphorodiamidateMorpholino Oligomers as NovelAntiviral Compounds,  Frontiers in Microbiology , 2018, (影响因子:4.32)

[3].  Yuchen Nan ;ChunyanWu * ;andYan-Jin Zhang * ; Interferon Independent Non‐Canonical STAT

Activation and Virus Induced Inflammation,  Viruses,  2018, (影响因子:3.7)

[4].Yiyang Chen, Baoyuan Liu, Yani Sun, HuixiaLi,Taofeng Du, Yuchen Nan, Julian A. Hiscox, En-Min Zhou,Qin Zhao;Characterization of Three Novel Linear Neutralizing B-Cell Epitopes in the Capsid Protein of Swine Hepatitis E Virus,  Journal of Virology,  2018, (影响因子:4.6)

[5].LiangliangLi; BiyunXu; WeiyaoSun; GuoqianGu; GaopengHou; LuZhang; ChunyanWu; QinZhao; YanjinZhang; GaipingZhang; Julian A.Hiscox;  YuchenNan* and En-MinZhou * ;Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5,  Antiviral Research,  2018, (影响因子:4.3通讯作者)

[6].Jie Li, Gang Wang, Di Yang, Bao Zhao, Yongpan Zhao, Yonggang Liu, Xuehui Cai,  Yuchen Nan ,En-Min Zhou* and Chunyan,2 * ;Development of luciferase-linked antibodycapture assay based on luciferaseImmunoprecipitation systems for antibodydetection of porcine reproductive andrespiratory syndrome virus,  BMC Biotechnology,  2018, (影响因子:2.7)

[7].Liping Yang, Rong Wang, Shixing Yang, Zexu Ma, Shaoli Lin,  Yuchen Nan , Qisheng Li Qiyi Tang, Yan-Jin Zhang*;Karyopherin Alpha 6 Is Required for Replication of PorcineReproductive and Respiratory Syndrome Virus and Zika Virus,  Journal of Virology,  2018, (影响因子:4.6)

2017年

[1].Taofeng Du,  Yuchen Nan,  Shuqi Xiao, Qin Zhaoand En-Min Zhou; Antiviral Strategies against PRRSV Infection,  Trends in Microbiology , 2017, (共同第一作者;影响因子:11.02)

[2]. Yuchen Nan Chunyan Wu, Guoqian Gu, Weirao Sun and En-Min Zhou; Improved Vaccine against PRRSV: Current progress and future perspective,  Frontiers in Microbiology , 2016, (影响因子:4.02)

[3].LipingYang, Rong Wang, Zexu Ma, Yueqiang Xiao,  Yuchen Nan , Yu Wang, Shaoli Lin and Yan-Jin Zhang. Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via Nsp5 by Inducing STAT3 Degradation,  Journal of Virology , 2017, 91, (影响因子:4.6)

[4].Shahid Faraz Syed, Yani Sun, TaofengDua, Yiyang Chen, Baoyuan Liu, XinjieWanga,Huixia Li, Yuchen Nan, En-Min Zhou and Qin Zhao. Evaluation of recombinant Chinese avian hepatitis E virus (CaHEV) ORF2and ORF3 proteins for protection of chickens against CaHEV infection, Vaccine, 2017,(35)3482–3489,(影响因子:3.235)

[5]. Zexu Ma, Ying Yu, Yueqiang, Xiao, Tanja Opriessnig, Rong Wang, Lipiong Yang,  Yuchen Nan , Siba K Samal, Patrick G Halbur and Yan-Jin Zhang, The middle half genome of interferon-inducing porcine reproductive and respiratory syndrome virus strain A2MC2 is essential for interferon induction,  Journal of General Virology , 2017,(影响因子:3.18)

2016年

[1].  Yuchen Nan  and Yan-Jin Zhang; Molecular Biology and Infection of Hepatitis E Virus,  Frontiers in Microbiology , 2016, (通讯作者;影响因子:4.12)

[2]. YonglinYang,Shaoli Lin, Yuchen Nan , Zexu Ma, Liping Yang, and Yan-JinZhang; A Linear Surface Epitope in a Proline-Rich Region of ORF3 Product of Genotype 1 Hepatitis E Virus.  Viruses  8(8). 2016, doi: 10.3390/v8080227,(影响因子:3.042)

[3]. JimingGao, ShuqiXiao,Yihong Xiao, XinjieWang, Zhang C, Qin Zhao,  Yuchen Nan  , BaichengHuang , HongliangLiu, Liu N, Lv J, Du T, Sun Y, Mu Y, Wang G, Syed SF, Zhang G, Hiscox JA, Goodfellow I, Zhou EM. 2016. MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection.  Scientific Report  6:25120;(影响因子:5.228)

[4].YonglinYang,  Yuchen Nan , Cai, Jie, Xu, Jiling, Zuhu Huang, Xubing Cai, The Thr to Met substitution of amino acid 118 in Hepatitis B virus surface Antigen escapes from immune assay based screening of blood Donors,  Journal of General Virology ; 2016;97:1210-1217;(影响因子:3.192)

[5]. Yueqiang Xiao, Zexu Ma , Rong Wang, Liping Yang,  Yuchen Nan , Yan-JinZhang, Downregulation of protein kinase PKR activation by porcine reproductive and respiratory syndrome virus at its early stage Infection,  Veterinary Microbiology , 2016, 187: 1-7;(影响因子:2.564)

[6]. ZexuMa , Ying Yu, Yueqiang Xiao, Tanja Opriessnig, Rong Wang, Liping Yang,  Yuchen Nan , Siba K. Samal, Patrick Gerard Halbur and Yan-JinZhang, Sustaining Interferon Induction by a High-Passage Atypical Porcine Reproductive and Respiratory Syndrome Virus Strain,  Scientific Reports , 2016, 6:36312;(影响因子:5.228)

2015年

[1].  Yuchen Nan  ,Ma, Zexu,Kannan, Harilakshmi,Stein, David A,Iversen,Patrick ,Meng, Xiang-Jin,Zhang, Yan-Jin, Inhibition of hepatitis E virusreplication by peptide-conjugated morpholino oligomers., AntiviralResearch , 2015, 120: 134-139; (影响因子:4.909)

[2]. New insights into virus–cell interactions during HEV infection: The double roles of HEV in IFNs induction (邀稿文章). Chunyan Wu,  Yuchen Nan  and Yan-Jin Zhang;Future Virology; 2015;10(4): 439-448 (共同第一作者) (影响因子:1.0)

2014年

[1].  Yuchen Nan , Guoxin Nan and Yan-Jin Zhang: Interferon Induction and Antagonism by RNA Viral Pathogens.  Viruses; 2014,  6 (12), 4999-5027(影响因子:3.042)

[2].  Yuchen Nan , Ying Yu, Zexu Ma, Sunil Khattar, Brenda Fredericksen, and Yan-Jin Zhang: Hepatitis E Virus Inhibits Type I Interferon Induction by ORF1 Product.  Journal of Virology ;2014; 88(15): 01935-14;(影响因子:4.606)

[3].  Yuchen Nan , Zexu Ma, Rong Wang, Ying Yu, andYan-Jin Zhang: Enhancement of interferon induction by ORF3 product of hepatitis E virus.  Journal of Virology ; 2014; 88(15):8696-705;(影响因子:4.606)

2013年

[1]. Rong Wang, Yueqiang Xiao, Tanja Opriessnig, Yi Ding, Ying Yu,  Yuchen Nan , Zexu Ma, Patrick G Halbur, Yan-Jin Zhang: Enhancing neutralizing antibody production by an interferon-inducing porcine reproductive and respiratory syndrome virus strain.  Vaccine ; 2013; 31(47):5534-43. ;(影响因子:3.413)

[2]. Rong Wang,  Yuchen Nan , Ying Yu, Zengqi Yang, and Yan-Jin Zhang: Variable interference with interferon signal transduction by different strains of porcine reproductive and respiratory syndrome virus.  Veterinary Microbiology ; 2013; 166(3-4):493-503.;(影响因子:2.564)

[3]. Ying Yu, Rong Wang,  Yuchen Nan , and Yan-Jin Zhang: Induction of STAT1 Phosphorylation at Serine 727 correlates with elevation of inflammatory gene expression by PRRSV.  PLoS One  2013; 8(4):e61967. doi: 10.1371/journal.pone.0061967;(影响因子:3.057)

[4].Rong Wang,  Yuchen Nan , Ying Yu, and Yan-Jin Zhang: Porcine Reproductive and Respiratory Syndrome Virus Nsp1β Inhibits Interferon-Activated JAK/STAT Signal Transduction by Inducing Karyopherin-α1 Degradation,  Journal of Virology  2013; 87(9):5219-28.;(影响因子:4.606)

2012年

[1]. Yuchen Nan , Rong Wang, Meiyan Shen, Kay S. Faaberg, Siba K. Samal, and Yan-Jin Zhang: Induction of Type I Interferons by a Novel Porcine Reproductive and Respiratory Syndrome Virus Isolate.  Virology  2012; 432:261-270;(影响因子:3.200)

[2]. Yanjin Zhang, Deendayal Patel, Yuchen Nan andSumin Fan: Inhibition of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers.  International Journal of Molecular Medicine, 2012, 30:S33-S33; (影响因子:2.348)

[3].KritRitthipichai,  Yuchen Nan , IoannisBossis, Yan-Jin Zhang: Viral FLICE Inhibitory Protein of Rhesus Monkey Rhadinovirus Inhibits Apoptosis by Enhancing Autophagosome Formation.  PLoS ONE 2012; 7(6): e39438. doi:10.1371/journal.pone.0039438;(影响因子:3.057)

2011年

[1].Yan-Jin Zhang, Deendayal Patel,  Yuchen Nan , and Sumin Fan: Inhibition of Early Lytic Genes of Kaposi’s Sarcoma-Associated Herpesvirus by Antiviral Morpholino Oligomers Leads to Engraftment Suppression of Primary Effusion Lymphoma in SCID Mice.  Antiviral Therapy  2011; 16:657-66;(影响因子:3.774)

2010年

[1].Deendayal Patel,  Yuchen Nan , Meiyan Shen, KritRitthipichai,Xiaoping Zhu, and Yan-Jin Zhang: Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I IFN Signaling by Blocking STAT1/STAT2 Nuclear Translocation, Journal of Virology , 2010. 84(21):11045-11055;(共同第一作者) (影响因子:5.06)

[2]. Yuchen Nan ,Deendayal Patel andYan-Jin Zhang: Inhibition of KSHV-associated lymphoma engraftment in SCID mouse by morpholino oligomers, Infectious Agents and Cancer ,2010. 5(Suppl 1);(影响因子:1.718)

9.联系方式

陕西省咸阳市杨凌区西农路22号西北农林科技大学动物医学院4254号

邮件:nanyuchen2015@nwsuaf.edu.cn; nyc@umd.edu; nycmjc@hotmail.com;

联系电话:13309312688


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