南雨辰

作者: 来源: 发布日期:2021-11-05 浏览次数:

1. 个人基本信息南雨辰副教授.jpg

南雨辰,男,1985年出生,美国马里兰大学分子病毒学博士学位;陕西省人才项目入选者;仲英青年学者;西北农林科技大学首批“高层次人才发展支持计划”青年拔尖人才B1岗。 2015年9月入职西北农林科技大学动物医学院,担任博士生导师;副教授 。现任西北农林科技大学党外知识分子联谊会(知联会)秘书长,杨凌示范区党外知识分子联谊会秘书长,动物医学院预防兽医系副主任。主要从事家畜重大病毒性疫病致病机制研究,累计发表SCI论文70余篇,其中第一作者及通讯作者论文30余篇。主持“十四五”国家重点研发计划青年科学家项目1项,国家自然科学基金面上项目2项,“十三五”国家重点研发计划课题1项,陕西省人才项目,陕西省引进人才专项,陕西省农专资金,人社部留学人员科技活动择优资助,中国科协****托举计划项目等省部及项目10余项,同时与企业开展横向产业化课题多项。兼任国家自然科学基金通讯评审专家;科技部及教育部在库专家;江西华牧生物科技有限公司夏咸柱院士工作站专家组成员;陕西诺威利华生物科技有限公司驻点技术专家。

2. 教育经历

2003年-2007年: 西北农林科技大学动物医学专业本科;

2007年-2009年: 西北农林科技大学预防兽医学硕士(出国直博未获硕士学位);

2009年-2014年: 美国马里兰大学,分子病毒学, 博士(Ph. D.);

3. 工作经历

2014年-2015年:美国马里兰大学, 博士后;

2015年至今:西北农林科技大学动物医学院,博士生导师;副教授;

2018年至今:西北农林科技大学党外知识分子联谊会(知联会)秘书长;

2020年至今:杨凌示范区党外知识分子联谊会秘书长;

4. 研究方向

(1)戊型肝炎病毒(HEV),非洲猪瘟病毒(ASFV)及猪繁殖与呼吸道综合征病毒(PRRSV)与宿主细胞相互作用机制;

(2)ASFV与PRRSV新型疫苗研发;

(3)病毒源朊病毒的鉴定及其生物学意义

5. 教学工作

本科生:《免疫生物学》(全英文课程);《病毒学》(中英双语课程、全英文课程);

参讲本科生《兽医免疫学》;博士生《兽医学专题》及硕士生《兽医免疫学》;

6.在研科研项目

(1)十四五国家重点研发计划青年科学家项目(2022-2025):免疫肽组库技术在猪基因工程疫苗精准设计中的探索及应用;200万;主持;

(2)国家自然科学基金面上项目(2022-2025):戊型肝炎病毒ORF3蛋白的朊病毒样特性在病毒致病中的作用;58万;主持;

(3)新疆方牧生物科技有限公司横向课题(2021-2025):非洲猪瘟基因工程亚单位疫苗一期:150万;主持;

(4)金宇保灵生物药品有限公司(2021-2025):非洲猪瘟病毒核酸疫苗研发;300万

(5)新疆方牧生物科技有限公司捐赠项目(2021-2023):重大动物疫病防控新技术研发与人才培养;150万;主持

(6)陕西省2022年度农业专项资金(2022-2023): 10万;主持

7.结题科研项目

(1)西北农林科技大学引进人才科研启动经费:戊型肝炎致病机制;100万;主持;

(2)十三五国家重点研发计划“动物疫病生物防治性制剂研制与产业化项目-课题4新型治疗性动物基因工程抗体研制(课题编号:2017YFD0501004)”:320万;主持;

(3)国家自然科学基金面上项目:猪戊型肝炎病毒抑制宿主干扰素信号通路机制;61万(批准号码:31672534);主持;

(4)陕西省人才项目经费:25万;主持;

(5)陕西省引进人才专项经费:20万;主持;

(6)陕西省2021年度农业专项资金:10万;主持;


7. 学术兼职

(1)美国病毒学会(American Society of Virology)正式会员

(2)国家自然科学基金生命科学八处通讯评审专家

(3)科技部/教育部在库专家,

(4)兼任下列杂志特邀审稿人( Ad hoc Reviewer )

Journal of Immunology

Frontiers in Immunology

Frontiers in Microbiology

Veterinary Microbiology,

Virology

Beneficial Microbes

World Journal of Gastroenterology

Virus Research

Veterinary Immunology and Immunopathology,

8. 发表论文及获得专利

(1)专利

美国专利

United States Patent Granted (专利号码:8906385B2): An Interferon-inducing Porcine Reproductive and Respiratory Syndrome Virus Isolate. Patent application granted. (申请日期 filed date: Dec 3, 2012, 批准日期granted date Oct 16, 2014专利生效日期Dec 9, 2014,专利保护期20年)

链接Link: http://www.google.com/patents/US20130183329

中国专利(第一发明人)

PRRSV广谱中和单克隆抗体5D9及其应用(专利号:ZL 2020 1 0069336.9);

一种免疫增强剂及其在疫苗制备中的应用(专利号:ZL 2020 1 0069365.5);

一种用于预防和治疗PRRSV感染的抗体药物(专利号:ZL 2020 1 0354506.8)

一种PRRSV广谱中和单克隆抗体及其应用(专利号:ZL 2020 1 0355075.7)

(2)代表性论文

2022年

[1]. Rui Chen, Bing Liu, Xiangmei Zhang, Mengmeng Qin, Jianhui Dong, Guoqian Gu, Chunyan Wu, Jingyu Wang* and  Yuchen Nan  * ;A porcine reproductive and respiratory syndrome virus (PRRSV)-specific IgM as a novel adjuvant for an inactivated PRRSV vaccine improves protection efficiency and enhances cell-mediated immunity against heterologous PRRSV challenge. Veterinary Research,(中科院2区,Top期刊) 2021, (影响因子:3.683,通讯作者)

[2]. Beibei Zhang, Mengnan Fan, Jie Fan, Yuhang Luo, Jie Wang, Yajing Wang, Baoyuan Liu, Yani Sun, Qin Zhao, Julian A Hiscox,  Yuchen Nan  *  and En-Min Zhou; Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization, Microbiology Spectrum , (中科院1区,Top期刊) 2021, (影响因子:9.043,通讯作者)

2021年

[1]. Zhigang Zhang, Tianshu Zhai, Mingshuo Li, Kun Zhang, Jingrui Li, Xu Zheng, Chaonan Tian, Rui Chen, Jianhui Dong, En-Min Zhou*,  Yuchen Nan  *  and Chunyan Wu*; A broadly neutralizing monoclonal antibody induces broad protection against heterogeneous PRRSV strains in piglets,  Veterinary Research, (中科院2区,Top期刊) 2021, (影响因子:3.683,通讯作者)

[2]. Chengbo Zhu, Jingrui Li, Chaonan Tian, Mengmeng Qin, Zhenni Wang, Bingjun Shi, Guanggang Qu*, Chunyan Wu* and  Yuchen Nan  * ; Proteomic Analysis of ISGylation in Immortalized Porcine Alveolar Macrophage Cell Lines Induced by Type I Interferon,  Vaccines, (中科院2区) 2021, (影响因子:4.422,通讯作者)

[3]. Xiaohui Ju, Fang Li, Jingrui Li, Chunyan Wu, Guangtao Xiang Xiaomin Zhao,  Yuchen Nan* , Dongming Zhao * and Qiang Ding * ; Genome-wide transcriptomic analysis of highly virulent African swine fever virus infection reveals complex and unique virus host interaction,  Veterinary Microbiology, (中科院2区,Top期刊) 2021, (影响因子:3.293,通讯作者);

[4]. Zhaobin Zhou, Yinqian Xie, Chunyan Wu*, and  Yuchen Nan* ; The Hepatitis E Virus Open Reading Frame 2 Protein: Beyond Viral Capsid,  Frontiers in Microbiology, (中科院2区,Top期刊) 2021, (影响因子:5.646,通讯作者);

[5]. Jie Wang, Yajing Wang, Bing Liu, Yunwei He, Zhiwei Li, Qin Zhao,  Yuchen Nan*  and Chunyan Wu; Porcine epidemic diarrhea Virus envelope protein blocks SLA-DR expression in barrow-derived dendritic cells by inhibiting promoters activation,  Frontiers in Immunology, (中科院2区,Top期刊) 2021, (影响因子:7.561,通讯作者);

2020年

[1]. Chunyan Wu, Bingjun Shi, Di Yang, Kun Zhang, Jie Li, Jie Wang, Hongliang Liu, Qin Zhao, En-Min Zhou* and  Yuchen Nan* ; Porcine Reproductive and Respiratory Syndrome Virus promotes SLA-DR-mediated antigen presentation of non-structure proteins to evoke a non-neutralizing antibody response  in vivo ,  Journal of Virology, (双一流G2类) 2020, (影响因子:5.103,通讯作者)

[2]. Yafei Li, Junhui Li, Sun He, Wei Zhang, Jian Cao, Xiaomei Pan, Huifen Tang, En-Min Zhou *,Chunyan Wu* and  Yuchen Nan* ; Interferon Inducing Porcine Reproductive and Respiratory Syndrome Virus Vaccine Candidate Protected Piglets from HP-PRRSV Challenge and Evoke a Higher Level of Neutralizing Antibodies Response,  Vaccines, (中科院2区)2020, (影响因子:4.086,通讯作者)

[3]. Xiaohui Ju, Guangtao Xiang, Mingli Gong, Rui Yang, Jierui Qin, Yafei Li,  Yuchen Nan,  Yonglin Yang, Qiangfeng Cliff Zhang, Qiang Ding; Identification of Functional cis-acting RNA Elements in Hepatitis E Virus Genome Required for Virus Replication,  PLoS pathogen, (双一流G2类)2020, (影响因子:6.463)

[4]. Chunyan Wu, Guoqian Gu, Tianshu Zhai, Yajing Wang, Yongling Yang, Yafei Lia, Xu Zheng, Qin Zhao, En-Min Zhou∗ and Yuchen Nan∗; Broad neutralization activity against both PRRSV-1 and PRRSV-2 and enhancement of cell mediated immunity against PRRSV by a novel IgM monoclonal antibody,  Antiviral Research, (中科院2区)2020, (影响因子:5.970,通讯作者)

[5]. Yan Wang, Rui Li, Songlin Qiao, Jiaxi Wang, Hongliang Liu, Zhijun Li, Hongfang Ma, Lei Yang, Haiyu Ruan, Maoyang Weng, Julian A Hiscox, James P Stewart, Yuchen Nan∗ , Gaiping Zhang∗, En-Min Zhou∗; Structural Characterization of Non-structural Protein 9 Complexed With Specific Nanobody Pinpoints Two Important Residues Involved in Porcine Reproductive and Respiratory Syndrome Virus Replication,  Frontiers in Microbiology  (中科院2区,Top期刊),  2020, (影响因子:5.646,通讯作者)

2019年

[1]. Lizhen Wang, Lu Zhang, Baichen Huang, Kuokuo Li, Gaopeng Hou, Qin Zhao, Chunyan Wu,  Yuchen Nan,  Taofeng Du, Yang Mu, Jixun Lan, Hongying Chen and En-Min Zhou*; A Nanobody Targeting Viral Non-Structural Protein 9 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication,  Journal of Virology (双一流G2类) ,  2019, (影响因子:5.103)

[2]. Tianshu Zhai, Chunyan Wu, Nana Wang, Binjun Shi, Jie Li, Rui Chen, Jianhui Dong, Yiying Zhanga, En-Min Zhou and  Yuchen Nan* ; Development of a monoclonal antibody against swine leukocyte antigen (SLA)-DR α chain and evaluation of SLA-DR expression in bone marrow derived dendritic cells after PRRSV infection,  Veterinary Immunology and Immunopathology, (中科院3区),2019, (影响因子:1.7通讯作者)

[3]. Pengfei Li, Zixiang Zhu, Xiangle Zhang, Wen Dang, Linlin Li, Xiaoli Du, Miaotao Zhang, Chunyan Wu, Qinghong Xue, Xiangtao Liu, Haixue Zheng* and and  Yuchen Nan* ; The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT Pathway,  Viruses  ( 中科院2区 ),  2019, (影响因子:5.048通讯作者)

[4]. Gaopeng Hou, Biyun Xue, Liangliang Li,  Yuchen Nan , Lu Zhang, Kuokuo Li, Qin Zhao, Julian Hiscox, James Stewart, Chunyan Wu*, Jingfei Wang* and En-Min Zhou*; Direct interaction between CD163 N-terminal domain and MYH9 C-terminal domain contributes to porcine reproductive and respiratory syndrome virus internalization by permissive cells,  Frontiers in Microbiology  (中科院2区,Top期刊),  2019, (影响因子:5.646)

[5]. Donglei Sun, Peng Sun, Hongmei Li, Mingshun Zhang, Gongguan Liu, Ashley B. Strickland, Yanli Chen, Yong Fu, Juan Xu, Mohammed Yosri,  Yuchen Nan,  Hong Zhou, Xiquan Zhang and Meiqing Shi*; Fungal dissemination is limited by liver macrophage filtration of the blood,  Nature Communication  (双一流G1类),  2019, (影响因子:12.1)

[6]. Biyun Xue, Gaopeng Hou, Guixi Zhang, Jingjing Huang, Liangliang Li,  Yuchen Nan , Yang Mu, Lizhen Wang, Lu Zhang, Ximeng Han, Xiaolei Ren, Qin Zhao, Chunyan Wu * , Jingfei Wang *  and En-Min Zhou * ; MYH9 Aggregation Induced by Direct Interaction with PRRSV GP5 Ectodomain Facilitates Viral Internalization by Permissive Cells,  Frontiers in Microbiology  (中科院2区,Top期刊),  2019, (影响因子:5.646)

[7]. Huixia Li, Mengnan Fan, Baoyuan Liu, Pinpin Ji, Yiyang Chen, Beibei Zhang, Yani Sun, Baicheng Huang,  Yuchen Nan , Zhenzhao Sun, James P Stewart, Julian A Hiscox, Qin Zhao *  and En-Min Zhou * ; Chicken Organic Anion-Transporting Polypeptide 1A2, a Novel Avian Hepatitis E Virus (HEV) ORF2-Interacting Protein, Is Involved in Avian HEV Infection,  Journal of Virology  (双一流G2类),  2019, (影响因子:5.103)

2018年

[1].  Yuchen Nan,  Chunyan Wu, Qin Zhao, Yani Sun, Yan-Jin Zhang and En-Min Zhou * ; Vaccine development against zoonotic hepatitis E virus: unmet needs for public health,  Frontiers in Microbiology  (中科院2区,Top期刊) , 2018, (影响因子:5.646)

[2].  Yuchen Nan* ; and Yan-Jin Zhang * ; Antisense Phosphorodiamidate Morpholino Oligomers as Novel Antiviral Compounds,  Frontiers in Microbiology  (中科院2区,Top期刊) , 2018, (影响因子:5.646,通讯作者)

[3].  Yuchen Nan* ; Chunyan Wu * ; and Yan-Jin Zhang * ; Interferon Independent Non‐Canonical STAT Activation and Virus Induced Inflammation,  Viruses  (中科院2区),  2018, (影响因子:5.048,通讯作者)

[4]. Yiyang Chen, Baoyuan Liu, Yani Sun, Huixia Li,Taofeng Du,  Yuchen Nan,  Julian A. Hiscox, En-Min Zhou, Qin Zhao; Characterization of Three Novel Linear Neutralizing B-Cell Epitopes in the Capsid Protein of Swine Hepatitis E Virus,  Journal of Virology  (双一流G2类),  2018, (影响因子:5.103)

[5]. Liangliang Li; Biyun Xu; Weiyao Sun; Guoqian Gu; Gaopeng Hou; Lu Zhang; Chunyan Wu; Qin Zhao; Yanjin Zhang; Gaiping Zhang; Julian A. Hiscox;  Yuchen Nan*  and En-Min Zhou * ; Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5,  Antiviral Research  (中科院2区),  2018, (影响因子:5.970,通讯作者)

[6]. Liping Yang, Rong Wang, Shixing Yang, Zexu Ma, Shaoli Lin,  Yuchen Nan , Qisheng Li Qiyi Tang, Yan-Jin Zhang*; Karyopherin Alpha 6 Is Required for Replication of Porcine Reproductive and Respiratory Syndrome Virus and Zika Virus,  Journal of Virology  (双一流G2类),  2018, (影响因子:5.103)

2017年

[1]. Taofeng Du#,  Yuchen Nan # ,  Shuqi Xiao, Qin Zhao and En-Min Zhou*; Antiviral Strategies against PRRSV Infection,  Trends in Microbiology (双一流G1类), 2017, (共同第一作者;影响因子:17.079)

[2].  Yuchen Nan , Chunyan Wu, Guoqian Gu, Weirao Sun and En-Min Zhou*; Improved Vaccine against PRRSV: Current progress and future perspective,  Frontiers in Microbiology (中科院2区,Top期刊), 2016, (影响因子:5.646)

[3]. Liping Yang, Rong Wang, Zexu Ma, Yueqiang Xiao,  Yuchen Nan , Yu Wang, Shaoli Lin and Yan-Jin Zhang*. Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via Nsp5 by Inducing STAT3 Degradation,  Journal of Virology (双一流G2类), 2017, 91, (影响因子:5.103)

[6].Yuchen Nan, Chunyan Wu, Qin Zhao and En-Min Zhou*; Zoonotic Hepatitis E Virus: An Ignored Risk for Public Health;  Frontiers in Microbiology (中科院2区,Top期刊), 2016, (影响因子:5.646)

[7].Yuchen Nan*, Chunyan Wu* and Yan-Jin Zhang*;Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism;  Frontiers in Immunology (中科院2区,Top期刊), 2017, (通讯作者;影响因子:7.561)

2016年

[1].  Yuchen Nan * and Yan-Jin Zhang*; Molecular Biology and Infection of Hepatitis E Virus,  Frontiers in Microbiology  (中科院2区) , 2016, (通讯作者;影响因子:5.646)

[2]. Zexu Ma , Ying Yu, Yueqiang Xiao, Tanja Opriessnig, Rong Wang, Liping Yang,  Yuchen Nan , Siba K. Samal, Patrick Gerard Halbur and Yan-Jin Zhang, Sustaining Interferon Induction by a High-Passage Atypical Porcine Reproductive and Respiratory Syndrome Virus Strain,  Scientific Reports , 2016, 6:36312;(影响因子:4.379)

2015年

[1].  Yuchen Nan ,Ma, Zexu,Kannan, Harilakshmi,Stein, David A,Iversen, Patrick ,Meng, Xiang-Jin,Zhang, Yan-Jin, Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers., Antiviral Research (中科院2区), 2015, 120: 134-139; (影响因子:5.970)

[2]. New insights into virus–cell interactions during HEV infection: The double roles of HEV in IFNs induction (邀稿文章). Chunyan Wu,  Yuchen Nan and Yan-Jin Zhang; Future Virology; 2015;10(4): 439-448 (共同第一作者) (影响因子:1.0)

2014年

[1]. Yuchen Nan , Guoxin Nan and Yan-Jin Zhang: Interferon Induction and Antagonism by RNA Viral Pathogens.  Viruses (中科院2区) ;  2014,  6 (12), 4999-5027(影响因子:5.048)

[2]. Yuchen Nan , Ying Yu, Zexu Ma, Sunil Khattar, Brenda Fredericksen, and Yan-Jin Zhang: Hepatitis E Virus Inhibits Type I Interferon Induction by ORF1 Product.  Journal of Virology (双一流G2类);2014; 88(15): 01935-14;(影响因子:5.103)

[3]. Yuchen Nan , Zexu Ma, Rong Wang, Ying Yu, and Yan-Jin Zhang: Enhancement of interferon induction by ORF3 product of hepatitis E virus.  Journal of Virology (双一流G2类); 2014; 88(15):8696-705;(影响因子:5.103)

7.联系方式

陕西省咸阳市杨凌区西农路22号西北农林科技大学动物医学院4254号

邮件:nanyuchen2015@nwsuaf.edu.cn; nyc@umd.edu;