萧 飒

作者:   来源:  发布日期:2016-04-25 浏览次数:

  一、个人基本信息

  姓名: 萧飒;籍贯:吉林;学位:博士;

  职称:教授; 指导教师资格:博士生导师。

  二、求学经历

  1986-1990年 北京农学院畜牧专业 学士

  1992-1993年 中国科学院研究生院在职研究生基础课学习

  1996-2001年 日本京都大学分子微生物学专业 博士  

  三、工作经历

  1990-1996年 中国科学院遗传研究所,实习研究员

  2002-2006年 美国纽约西奈山医学院,博士后

  2007-2013年 美国马里兰大学兽医学院,研究助理

  2013.09-至今 西北农林科技大学动物医学院,教授

  四、研究方向

    1.新城疫病毒及其他禽副粘病毒的遗传学特性及流行病学。

  2.新城疫病毒的神经致病机理。

  3.病毒的分子致病机制。

  4.病毒与宿主的相互作用。

  5.RNA病毒的反向遗传系统、诊断及疫苗的研发。

  五、讲授课程

  兽医传染病学,兽医流行病学,兽医传染病学实验,兽医传染病学实习,动物疫病防控专题。

  六、科研项目

  1.国家自然科学基金面上项目(31572533),主持。

  2.西北农林科技大学人才引进科研启动资金。

  七、发表SCI论文(近年)

  1.Guo Y, Zhao J, Chang X, Yao W, Wang H, Wang W, Wang X, Zhang S, Yang Z, Xiao S. α2,3- and α2,6-Linked Sialic Acids are Important for Cell Binding and Replication of Newcastle Disease Virus in Chicken Primary Neuronal Cells. Acta Virologica. 2018. In press.

  2.Wang X, Wang X, Jia Y, Wang C, Tang Q, Han Q, Xiao S, Yang Z. Coadministration of Recombinant Adenovirus Expressing GM-CSF with Inactivated H5N1 Avian Influenza Vaccine Increased the Immune Responses and Protective Efficacy Against a Wild Bird Source of H5N1 Challenge.J Interferon Cytokine Res. 2017. 37(10):467-473.

  3.Wang Y, Bi Y, Yu W, Wei N, Wang W, Wei Q, Wang X, Zhang S, Yang Z, Xiao S. Two mutations in the HR2 region of Newcastle disease virus fusion protein with a cleavage motif "RRQRRL" are critical for fusogenic activity. Virol J. 2017. 14(1):185.

  4.Wang Y, Yu W, Huo N, Wang W, Guo Y, Wei Q, Wang X, Zhang S, Yang Z, Xiao S. Comprehensive analysis of amino acid sequence diversity at the F protein cleavage site of Newcastle disease virus in fusogenic activity. PLoS One. 2017. 12(9):e0183923.

  5.Ren S, Xie X, Wang Y, Tong L, Gao X, Jia Y, Wang H, Fan M, Zhang S, Xiao S, Wang X, Yang Z. Molecular characterisation of a Class I Newcastle disease virus strain isolated from pigeon in China. 2016. Avian Pathol. 7:1-34.

  6.Kim SH, Xiao S, Collins PL, Samal SK. LaSota F Cleavage Motif-Mediated Fusion Activity Is Affected by Other Regions of F Protein from Different Genotype Newcastle Disease Virus in a Chimeric Virus: Implication for Virulence Attenuation. 2016. J Gen Virol. doi:10.1099.

  7.Gao X, Hu X, Tong L, Liu D, Chang X, Wang H, Dang R, Wang X, Xiao S, Du E, Yang Z. Construction of a camelid VHH yeast two-hybrid library and the selection of VHH against haemagglutinin-neuraminidase protein of the Newcastle disease virus. 2016. BMC Vet Res. 12(1):39.

  8.Liu Q, Yang Z, Hao H, Cheng S, Fan W, Du E, Xiao S, Wang X, Zhang S. Development of a SYBR Green real-time RT-PCR assay for the detection of avian encephalomyelitis virus. J. Virol. Methods. 2014 Sep;206:46-50.

  9.Paldurai A, Xiao S, Kim SH, Kumar S, Nayak B, Samal S, Collins PL, Samal SK. Naturally occurring six- and twelve-nucleotide inserts do not affect Newcastle disease virus replication and pathogenesis. PLoS One. 2014 Aug 5;9(8):e103951.

  10.Kim SH, Paldurai, A, Xiao S, Collins PL, Samal SK. Modified Newcastle Disease Virus Vectors Expressing the H5 Hemagglutinin Induce Enhanced Protection against Highly Pathogenic H5N1 Avian Influenza Virus in Chickens. Vaccine. 2014 Jul 31;32(35):4428-35.

  11.Paldurai A, Kim SH, Nayak B, Xiao S, Shive H, Collins PL, Samal SK. Evaluation of the contributions of the individual viral genes to Newcastle disease virus virulence and pathogenesis. J. Virol. 2014 Aug 1;88(15):8579-8596.

  12.Kim SH*, Xiao S*, Paldurai A, Collins PL, Samal SK. Role of C596 in the C-terminal extension of the haemagglutinin-neuraminidase protein in replication and pathogenicity of a highly virulent Indonesian strain of Newcastle disease virus.J. Gen. Virol. 2014 Feb; 95(Pt 2):331-6. *Co-author.

  13.Khattar SK, Nayak B, Kim SH, Xiao S, Samal S, Paldurai A, Buchholz UJ, Collins PL, Samal SK. Evaluation of the replication, pathogenicity, and immunogenicity of avian paramyxovirus (APMV) serotypes 2, 3, 4, 5, 7, and 9 in rhesus macaques. PLoS One. 2013 Oct 10;8(10):e75456.

  14.Kim SH, Wanasen N, Paldurai A, Xiao S, Collins PL, Samal SK. Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine. PLoS One. 2013 Aug 28;8(8):e74022.

  15.Xiao S, Paldurai A, Nayak B, Mirande A,  Collins PL & Samal SK. Complete genome sequence of a highly virulent Newcastle disease virus strain currently circulating in Mexico. Genome Announcement. 2013. Jan;1(1). doi:pii: e00177-12. 10.1128/genomeA.00177-12.

  16.Parthiban M, Manimaran K, Xiao S, Nayak B, Paldurai A, Kim SH, Ladman BS, Preskenis LA, Gelb Jr.G, Collins PL and Samal SK. Complete genome sequence of an avian paramyxovirus type 4 from North America reveals a shorter genome and new genotype. Genome Announcement. 2013. Jan;1(1). doi:pii: e00075-12. 10.1128/genomeA.00075-12.

  17.Kim SH, Xiao S, Shive H, Collins PL, Samal SK. Mutations in the Fusion Protein Cleavage Site of Avian Paramyxovirus Serotype 4 Confer Increased Replication and Syncytium Formation in vitro but not Increased Replication and Pathogenicity in Chickens and Ducks. PLoS One. 2013;8(1):e50598.

  18.Samuel A, Nayak B, Paldurai A, Xiao S, Aplogan GL, Awoume KA, Webby RJ, Ducatez MF, Collins PL, Samal SK. Phylogenetic and pathotypic characterization of Newcastle disease viruses circulating in West Africa and the efficacy of a current vaccine. Journal of Clinical Microbiology. 2013 Mar;51(3):771-81.

  19.Xiao S, Nayak B, Samuel A, Paldurai A, Kanabagattebasavarajappa M, Prajitno TY, Bharoto EE, Collins PL, Samal SK. Generation by reverse genetics of an effective, stable, live-attenuated Newcastle disease virus vaccine based on a currently circulating, highly virulent Indonesian strain. PLoS One. 2012. 7(12):e52751.

  20.Kim SH, Xiao S, Shive H, Collins PL, Samal SK. Replication, neurotropism, and pathogenicity of avian paramyxovirus serotypes 1-9 in chickens and ducks. PLoS One. 2012. 7(4): e34927.

  21.Xiao S, Paldurai A, Nayak B, Samuel A, Bharoto EE, Prajitno TY, Collins PL, Samal SK. Complete genome sequences of Newcastle disease virus strains circulating in chicken populations of Indonesia. J. Virol. 2012. 86(10): 5969-5970.

  22.Xiao S, Khattar SK, Subbiah M, Collins PL, Samal SK. Mutation of the F protein cleavage site of avian paramyxovirus-7 results in furin cleavage, fusion promotion and increased replication in vitro, but not increased replication, tissue tropism, or virulence in chickens. J. Virol. 2012.86(7): 3828-3838.

  发表中文论文:

  1.毕友坤,屈阳,卫巧林,王文彬,赵杰,霍娜,张淑霞,王兴龙,杨增岐,萧飒*。我国新城疫病毒强毒株 F48E9 致病性细化分型的鉴定。畜牧与兽医,2018,50(2):91-96。

  2.王重阳,任善会,贾燕青,王相伟,高小龙,张淑霞,萧飒,王兴龙*,杨增岐*。新城疫病毒LaSota及F48E9 毒株P和V及W蛋白C端功能域的原核表达及其多克隆抗体的制备。中国兽医科学,2017,47(4):411-418。

  3.范文涛,杜恩岐,高小龙,萧 飒,李志军,范莉莉,郝华芳,王兴龙,党如意,张淑霞*,杨增岐*。禽脑脊髓炎病毒VP1蛋白纳米抗体的筛选及活性检测。中国兽医学报,2016,36(1):12-17。

  4.高小龙,胡湘云,付向晶,王燕平,仝丽娜,王海新,王兴龙,张淑霞,萧 飒,杜恩岐*,杨增岐*。新城疫病毒F蛋白纳米抗体的筛选及活性鉴定。畜牧兽医学报,2016,47(8):1645-1651。

  5.王兴龙,邱立,党如意,杨增岐*,张淑霞,萧飒。兽医教学中的生物安全问题及对策建议。安徽农学通报,2015,21(2):93-95.

  八、联系方式

  通信地址:陕西,杨凌,西农路22号,邮编712100。

  电子邮箱:saxiao@nwafu.edu.cn


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