萧 飒

作者:   来源:  发布日期:2016-04-25 浏览次数:

       一、个人基本信息

  姓名: 萧飒;性别:男;出生年月:1966.03;籍贯:吉林;学位:博士;

  职称:教授;指导教师资格:博士生导师。

  二、求学经历

  1986-1990年北京农学院畜牧专业  学士

  1992-1993年中国科学院研究生院在职研究生基础课学习

  1996-2001年日本京都大学分子微生物学专业     博士

  三、工作经历

  1990-1996年中国科学院遗传研究所,实习研究员

  2002-2006年美国纽约西奈山医学院,博士后

  2007-2013年美国马里兰大学兽医学院,研究助理

  2013.09-至今西北农林科技大学动物医学院,教授

  四、研究方向

  1.新城疫病毒及其他禽副粘病毒的遗传学特性及流行病学。

  2.新城疫病毒的神经致病机理。

  3.病毒的分子致病机制。

  4.病毒与宿主的相互作用。

  5.RNA病毒的反向遗传系统、诊断及疫苗的研发。

  五、讲授课程

  兽医传染病学,兽医传染病学实验,兽医传染病学实习,动物疫病防控专题,兽医流行病学(2017年开设)。

  六、科研项目

  1.国家自然科学基金面上项目(31572533),主持人,起止日期:2016.01-2019.12

  2.西北农林科技大学人才引进科研启动资金。

  七、发表论文(近五年)

  1.Ren S, Xie X, Wang Y, Tong L, Gao X, Jia Y, Wang H, Fan M, Zhang S, Xiao S, Wang X, Yang Z. Molecular characterisation of a Class I Newcastle disease virus strain isolated from pigeon in China. 2016. Avian Pathol. 7:1-34.

  2.Kim SH, Xiao S, Collins PL, Samal SK. LaSota F Cleavage Motif-Mediated Fusion Activity Is Affected by Other Regions of F Protein from Different Genotype Newcastle Disease Virus in a Chimeric Virus: Implication for Virulence Attenuation. 2016. J Gen Virol. doi:10.1099.

  3.Gao X, Hu X, Tong L, Liu D, Chang X, Wang H, Dang R, Wang X, Xiao S, Du E, Yang Z. Construction of a camelid VHH yeast two-hybrid library and the selection of VHH against haemagglutinin-neuraminidase protein of the Newcastle disease virus. 2016. BMC Vet Res. 12(1):39.

  4.Liu Q, Yang Z, Hao H, Cheng S, Fan W, Du E, Xiao S, Wang X, Zhang S. Development of a SYBR Green real-time RT-PCR assay for the detection of avian encephalomyelitis virus. J. Virol. Methods.2014 Sep;206:46-50.

  5.Paldurai A,Xiao S, Kim SH, Kumar S, Nayak B, Samal S, Collins PL, Samal SK.Naturally occurring six- and twelve-nucleotide inserts do not affect Newcastle disease virus replication and pathogenesis.PLoS One.2014 Aug 5;9(8):e103951.

  6.Kim SH, Paldurai, A, Xiao S, Collins PL, Samal SK. Modified Newcastle Disease Virus Vectors Expressing the H5 Hemagglutinin Induce Enhanced Protection against Highly Pathogenic H5N1 Avian Influenza Virus in Chickens. Vaccine.2014 Jul 31;32(35):4428-35.

  7.Paldurai A, Kim SH, Nayak B, Xiao S, Shive H, Collins PL, Samal SK. Evaluation of the contributions of the individual viral genes to Newcastle disease virus virulence and pathogenesis.J. Virol. 2014 Aug 1;88(15):8579-8596.

  8.Kim SH*, Xiao S*, Paldurai A, Collins PL, Samal SK. Role of C596 in the C-terminal extension of the haemagglutinin-neuraminidase protein in replication and pathogenicity of a highly virulent Indonesian strain of Newcastle disease virus.J. Gen. Virol. 2014 Feb; 95(Pt 2):331-6. *Co-author.

  9.Khattar SK, Nayak B, Kim SH, Xiao S, Samal S, Paldurai A, Buchholz UJ, Collins PL, Samal SK. Evaluation of the replication, pathogenicity, and immunogenicity of avian paramyxovirus (APMV) serotypes 2, 3, 4, 5, 7, and 9 in rhesus macaques. PLoS One. 2013 Oct 10;8(10):e75456.

  10.Kim SH, Wanasen N, Paldurai A, Xiao S, Collins PL, Samal SK. Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine. PLoS One. 2013 Aug 28;8(8):e74022.

  11.Xiao S, Paldurai A, Nayak B, Mirande A,  Collins PL&Samal SK. Complete genome sequence of a highly virulent Newcastle disease virus strain currently circulating in Mexico. Genome Announcement.2013. Jan;1(1). doi:pii: e00177-12. 10.1128/genomeA.00177-12.

  12.Parthiban M, Manimaran K, Xiao S, Nayak B, Paldurai A, Kim SH, Ladman BS, Preskenis LA, Gelb Jr.G, Collins PL and Samal SK. Complete genome sequence of an avian paramyxovirus type 4 from North America reveals a shorter genome and new genotype. Genome Announcement.2013. Jan;1(1). doi:pii: e00075-12. 10.1128/genomeA.00075-12.

  13.Kim SH, Xiao S, Shive H, Collins PL, Samal SK. Mutations in the Fusion Protein Cleavage Site of Avian Paramyxovirus Serotype 4 Confer Increased Replication and Syncytium Formation in vitro but not Increased Replication and Pathogenicity in Chickens and Ducks. PLoS One. 2013;8(1):e50598.

  14.Samuel A, Nayak B, Paldurai A, Xiao S, Aplogan GL, Awoume KA, Webby RJ, Ducatez MF, Collins PL, Samal SK. Phylogenetic and pathotypic characterization of Newcastle disease viruses circulating in West Africa and the efficacy of a current vaccine. Journal of Clinical Microbiology.2013 Mar;51(3):771-81.

  15.Xiao S, Nayak B, Samuel A, Paldurai A, Kanabagattebasavarajappa M, Prajitno TY, Bharoto EE, Collins PL, Samal SK. Generation by reverse genetics of an effective, stable, live-attenuated Newcastle disease virus vaccine based on a currently circulating, highly virulent Indonesian strain. PLoS One2012. 7(12):e52751.

  16.Kim SH, Xiao S, Shive H, Collins PL, Samal SK. Replication, neurotropism, and pathogenicity of avian paramyxovirus serotypes 1-9 in chickens and ducks. PLoS One.2012. 7(4): e34927.

  17.Xiao S, Paldurai A, Nayak B, Samuel A, Bharoto EE, Prajitno TY, Collins PL, Samal SK. Complete genome sequences of Newcastle disease virus strains circulating in chicken populations of Indonesia. J. Virol. 2012. 86(10): 5969-5970.

  18.Xiao S, Khattar SK, Subbiah M, Collins PL, Samal SK. Mutation of the F protein cleavage site of avian paramyxovirus-7 results in furin cleavage, fusion promotion and increased replication in vitro, but not increased replication, tissue tropism, or virulence in chickens. J. Virol.2012.86(7): 3828-3838.

  19.Xiao S, Kumar M, Yang X, Akkoyunlu M, Collins PL, Samal SK, Pal U.A host-restricted viral vector for antigen-specific immunization against Lyme disease pathogen. Vaccine. 2011. 29(32):5294-5303.

  20.Khattar SK., Kumar S, Xiao S, Collins PL & Samal SK. Experimental infection of mice with avian paramyxovirus serotypes 1 to 9.PLoS One. 2011.6(2): e16776.

  21.Seto J., Qiao L., Guenzel C.A., Xiao S.,Shaw M.L., Hayot F.&Sealfon S.C. Novel Nipah virus immune-antagonism strategy revealed by experimental and computational study. J. Virol. 2010. 84(21):10965-73.

  22.Subbiah M, Xiao S, Khattar SK, Dias FM, Collins PL & Samal SK. Pathogenesis of two strains of avian paramyxovirus serotype 2, Yucaipa and Bangor, in chickens and turkeys.Avian Dis. 2010. 54(3):1050-7.

  23.Xiao S, Subbiah M, Kumar S, De Nardi R, Terregino C, Collins P.& Samal SK. Complete genome sequences of avian paramyxovirus serotype 6 prototype strain Hong Kong and a recent novel strain from Italy: evidence for the existence of subgroups within the serotype.Virus Res. 2010. 150(1-2):61-72.

  24.Kumar S, Nayak B, Samuel AS., Xiao S, Collins PL & Samal SK. Complete genome sequence of avian paramyxovirus-3 strain Wisconsin: evidence for the existence of subgroups within the serotype.Virus Res. 2010. 149(1):78-85.

  八、联系方式

  通信地址:陕西,杨凌,西农路22号,邮编712100。

  电子邮箱:saxiao@nwafu.edu.cn

  


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