赵善廷

作者:   来源:  发布日期:2015-09-29 浏览次数:

一、简介870da722519f4281b54f387d1cdbfe31.jpg

 赵善廷,男,1964年9月出生,山东高青县人,德国医学博士,西北农林科技大学“后稷学者”特聘教授,博士生导师,曾任兰州大学“萃英学者”特聘教授,西北农林科技大学图书馆馆长,校侨联副主席,元宝枫科研产业化发展研究中心副主任,杜仲研究所副所长,中美食品安全中心副主任,国家林业与草原局元宝枫工程技术研究中心副主任。

主要学习经历1980.9-1985.7:滨州医学院,临床医学专业,获学士学位 1985.9-1988.7:新疆医科大学,组织胚胎学专业,获硕士学位 1998.10-2001.1:德国Freiburg大学医学院, 获医学博士学位 2001.1-2004.9:德国Freiburg大学医学院,博士后 三、主要工作经历 1988.8-1998.9:新疆医科大学,组织胚胎学教研室,助教,讲师,副教授 1997.5-1998.4:德国Freiburg大学医学院,访问学者 2004.10-2011.09:德国Freiburg大学医学院,助理教授 2008.12-2011.3:兰州大学生命科学学院,“萃英学者”特聘教授,博士生导师 2011.01-至今:西北农林科技大学,“后稷学者”特聘教授,博士生导师;2017.2-2019.5:西北农林科技大学图书馆副馆长(主持工作);

2019.6-至今:西北农林科技大学图书馆馆长。

四、社会兼职

杨陵区政协委员,中国动物福利与健康养殖学会常务理事,美国神经科学学会会员,欧洲神经科学学会会员,中国神经科学学会会员,德国解剖学会会员,中国解剖学会会员,中国体视学会会。国际著名发育学神经生物学学术期刊“Development”“Journal of Neuroscience”“European Journal of Neuroscience”“Journal of Comparative Neurology”“Neuroscience”的审稿专家。

五、工作简介

在德国弗莱堡大学时主要以子宫内电击转染、器官型脑片培养、荧光免疫组化、高压冷冻电镜技术、激光共聚焦显微镜、活体动态观察显微镜等形态学技术和原位杂交、Western-blot、实时荧光定量PCR等分子生物学技术对大脑发育、成体神经干细胞及学习和记忆的机制等神经生物学热点问题进行了深入和细致的研究。回国后,在继续进行以上研究方向的基础上开展了食品安全、动物福利与健康养殖等方面的研究,近年来利用上述技术与肠道菌群和生物信息学相结合致力于中药和元宝枫籽对神经系统疾病特别是脑中风(脑血栓和脑溢血)、老年性痴呆和帕金森病等的预防和治疗临床应用和机理研究,阐明中药通过肠道菌群对脑肠轴的影响,取得了突破性进展,开发出了两款产品,经临床试用,显示出良好的疗效。另外,与相关企业合作,研究中药废弃物和元宝枫叶发酵产物在畜禽饲料无抗生素健康养殖中的应用,获得发明专利三项,指导和培养专业博士研究生和专业硕士研究生各两名。先后发表学术论文130余篇,其中在“Nature”子刊、“Journal of Neuroscience”、“Development”等国际著名学术杂志上发表SCI论文80余篇,累积影响因子超过350。自2002年以来作为主要人员参与德国及欧共体重大科研项目4项(相当于中国973项目),并主持一项子课题。回国后主持2项国家自然科学基金面上项目和2项省部级项目,作为主要成员参与国家和省部级课题多项。已指导博士后6名,博士生10名,硕士生24名,本实验室培养的研究生在学习期间多数获得国家奖学金,有6名硕士研究生毕业后获得国家留学基金委资助到欧美等国家攻读博士学位。本人多次应邀参加国内外学术会议并作大会报告.

六、回国后获资助情况:

1,科技部政府间国际科技创新合作重点专项(主要参与人),项目名称:杜仲叶林资源高值化利用关键技术研发,项目编号:2018YFE0127000 ,项目实施期限:2020.01-2022.12,资助金额:300万元.

2,陕西省重点研发计划项目(子课题负责人),项目名称:元宝枫资源培育与高效利用关键技术研究;项目编号:2018ZDXM2;项目执行时间:2019.01-2021.12;项目金额:20 万元.

3,陕西省重点研发计划项目(主要负责人),元宝枫油和神经酸营养和药用价值研究及相关产品开发,项目编号:2019ZDXM3-02,项目执行时间:2020.01-2022.12;项目金额:100万元。

4,国家自然科学基金面上项目(主持人):项目名称:苦马豆素对山羊海马的结构和功能的影响及机制,项目编号:31572477,资助金额:80万元,资助时间:2016-01至2019-12。

5,国家自然科学基金面上项目(主持人):项目名称:青海沙蜥成体神经发生及生态环境对它的影响,项目编号:31071873,资助金额:35万元,资助时间:2011-01至2013-12。

6,陕西省科技统筹项目(主持人):项目名称:基于动物福利的猪健康养殖关键技术研究,项目编号:2016KTCL02-19,资助金额:30万元,资助时间:2016-01至2017-12。

7,教育部留学回国人员启动基金(主持人):项目名称:极端环境对小鼠成体神经发生的影响,项目编号:200913,资助金额:4万元,资助时间:2009-01至2009-12。

8,西北农林科技大学“后稷学者”特聘教授,2011年,高层次人才启动基金:300万元。

七、获奖

1,第六届中国侨界创新成果贡献奖,神经生物学的基础研究及在畜禽健康养殖中的应用, 2016.9,中华全国归国华侨联合会。

2,陕西省高等教育教学成果奖-特等奖,编号:SJX171013-9,以培养卓越兽医人才为目标的专业基础课程改革与实践,第九名,2018.02.15,陕西省人民政府。

3,陕西省高等教育教学成果奖-二等奖,编号:SJX152016-3,以培养学生实践与创新能力为核心的动物解刨学与组织胚胎学教学改革与实践,第三名,2015.12.31,陕西省人民政府。

4,第十四届“挑战杯”全国大学生课外科技作品优秀指导教师,作品“RSP3亚细胞定位及其在小鼠大脑皮层发育中的功能研究”2015.11,共青团中央,中国科协和教育部。

八、代表性论著

SCI第一作者论文(IF:影响因子)

1,Chai X*, Zhao S* (equal contributed), Fan L, Zhang W, Lu X, Shao H, Wang S, Song L, Failla AV, Zobiak B, Mannherz HG, Frotscher M.Reelin and cofilin cooperate during the migration of cortical neurons: A quantitative morphological analysis. Development . 2016 Mar 15;143(6):1029-40(*并列第一作者)(IF ="7.3)

2,Studer D*, Zhao S* (equal contributed), Chai X, Jonas Peter, Graber W , Nestel S, Frotscher M. Capture of activity-induced ultrastructural changes at synapses by high-pressure freezing of brain tissue. Nature Protocols . 2014;9(6):1480-95.(*并列第一作者)(IF="7.950)

3,Zhao S, Studer D, Chai X, Graber W, Brose N, Nestel S, Young C, Rodriguez EP, Saetzler K, Frotscher M. Structural plasticity of spines at giant mossy fiber synapses.  Front Neural Circuits. 2012 6:103-110. (IF="3.385)

4,Zhao S, Studer D, Graber W, Nestel S, Frotscher M. Fine structure of hippocampal mossy fiber synapses following rapid high-pressure freezing.  Epilepsia. 2012;53 Suppl 1:4-8. (IF3=".909)

5,Zhao S, Studer D, Chai X, Graber W, Brose N, Nestel S, Young C, Rodriguez EP, Saetzler K, Frotscher M. Structural plasticity of hippocampal mossy fiber synapses as revealed by high-pressure freezing.  J Comp Neurol.  2012;520(11):2340-51. (IF="3.661)

6,Zhao S, Frotscher M. Go or stop? Divergent roles of Reelin in radial neuronal migration. Neuroscientist.  2010; 16(4):421-34. (IF="5.952)

7,Zhao S, Chai X, Bock HH, Brunne B, Forster E, Frotscher M. Rescue of the reeler phenotype in the dentate gyrus by wild-type coculture is mediated by lipoprotein receptors for Reelin and Disabled 1. JComp Neur ol. 2006; 495(1):1-9.(IF="3.661)

8,Zhao S, Chai X, Forster E, Frotscher M. Reelin is a positional signal for the lamination of dentate granule cells.  Development.  2004; 131(20):5117-5125.(IF ="7.3)

9,Zhao S, Forster E, Chai X, Frotscher M. Different signals control laminar specificity of commissural and entorhinal fibers to the dentate gyrus. J Neurosc  i  .  2003; 23(19):7351-7357.( IF="7.452)

10,Forster E*, Jossin Y*, Zhao S*, Chai X, Frotscher M, Goffinet AM(*并列第一作者). Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus.  Eur JNeurosci.  2006; 23(4):901-909.(IF="3.385)

11. Zhao S, Chai X, Frotscher M.Balance between neurogenesis and gliogenesis in the adult hippocampus: role for reelin. Dev Neurosci. 2007;29(1-2):84-90

SCI通讯作者论文(*通讯作者,IF:影响因子)

12.ShuzhongWang,XuzhaoLi,QianruZhang,XuejunChai,YiWang,EckartFörster,XiaoyanZhu*,ShantingZhao*.Nyap1RegulatesMultipolar–BipolarTransitionandMorphologyofMigratingNeuronsbyFynPhosphorylationduringCorticogenesis.  Cerebral Cortex. 2020,30:929-941.

13.Peng Chen, Maofang Hei, Lili Kong, Yinyin Liu, Yu Yang Haibo Mu, Xiuyun Zhang, Shanting Zhao* and Jinyou Duan* . One water-soluble polysaccharide from Ginkgo biloba leaves with antidepressant activities via modulation of the gut microbiome.  Food & Function. 2019,10(12):8161 - 8171

14.XiaoyanZhu*, YongjiWu, CixiaLi, WenyongYan, JiarongPan,Shuzhong Wang, Shanting, Zhao*. Prenatal Exposure to Gossypol Impairs Corticogenesis of Mouse. Frontiers in Neuroscience ; 2020,Apr 3,. DOI:10.3389/fnins.2020.00318

15.MengmengLiu, MingruiXu, MengliWang, ShuzhongWang, KaikaiLi, XinranCheng, YongjiWu, YiWang, XiaoyanZhu*, ShantingZhao*. Maternal exposure to swainsonine impaired the early postnatal development of mouse dentate gyrus of offspring.  Neurochemistry International,  129, 104511

16. Hei M, Chen P, Wang S, Li X, Xu M, Zhu X, Wang Y, Duan J, Huang Y*, Zhao S*.Effects of chronic mild stress induced depression on synaptic plasticity in mouse hippocampus. Behav Brain Res.  2019 Feb 27. pii: S0166-4328(18)31470-0. doi: 10.1016/j.bbr.2019.02.044.

17. Zhuang M, Li B, Huang Y, Lei Q, Yan R, Li N, Sidhu K, Cheng X, Yan X, Miao Y, Zhao S*, Hua J*.Reelin regulates male mouse reproductive capacity via the sertoli cells. J Cell Biochem.  2018 Oct 18. doi: 10.1002/jcb.26824.

18. Liu M, Li G, Wang M, Cheng X, Huang Y, Xu M, Li K, Chen J, Zhu X, Zhao S*.Further studies about Coactosin-like protein-1 affecting the migration of mouse neocortical neurons.J Mol Histol. 2018 Oct;49(5):519-530.

19. Cheng X, Li K, Liu M, Xu M, Hu X, Yan R, Förster E, Zhao S*.The effect of P85 on neuronal proliferation and differentiation during development of mouse cerebral cortex. Dev Biol . 2018 Sep 1;441(1):95-103.

20. Liu M, Cheng X, Li K, Xu M, Wu Y, Wang M, Zhang Q, Yan W, Luo C, Zhao S*Process in menstrual blood-derived mesenchymal stem cells for treatment of central nervous system diseases. Sheng Wu Gong Cheng Xue Bao . 2018 May 25;34(5):644-652.

21. Cheng X, Li K, Liu M, Hu X, Xu M, Yan R, Zhao S*.P85 regulates neuronal migration through affecting neuronal morphology during mouse corticogenesis. Cell Tissue Res. 2018 Apr;372(1):23-31.

22. An L, Li W, Hu X, Zhang W, Zhao S*.Abundant Focal Adhesion Kinase Causes Aberrant Neuronal Migration Via Its Phosphorylation at Tyr925. J Mol Neurosci. 2018 Jan;64(1):102-110.

23. Fang J, Wei Y, Teng X, Zhao S*, Hua J*.Immortalization of canine adipose-derived mesenchymal stem cells and their seminiferous tubule transplantation. J Cell Biochem. 2018 Apr;119(4):3663-3670. doi: 10.1002/jcb.26574. Epub 2018 Jan 11

24. Li X, Xie J, Hei M, Tang J, Wang Y, Förster E, Zhao S*.High level of CTP synthase induces formation of cytoophidia in cortical neurons and impairs corticogenesis. Histochem Cell Biol. 2018 Jan;149(1):61-73.(IF="2.5529)

25. Xu M, Huang Y, Li K, Cheng X, Li G, Liu M, Nie Y, Geng S, Zhao S*.Developmental exposure of decabromodiphenyl ether impairs subventricular zone neurogenesis and morphology of granule cells in mouse olfactory bulb. Arch Toxicol . 2018 Jan;92(1):529-539.(IF="5.9010)

26. Li K, Cheng X, Jiang J, Wang J, Xie J, Hu X, Huang Y, Song L, Liu M, Cai L, Chen L, Zhao S*.The toxic influence of paraquat on hippocampal neurogenesis in adult mice. Food Chem Toxicol . 2017 Aug;106(Pt A):356-366. (IF="3.7780)

27. Huang Y, Li G, An L, Fan Y, Cheng X, Li X, Yin Y, Cong R, Chen S, Zhao S*.Fyn regulates multipolar-bipolar transition and neurite morphogenesis of migrating neurons in the developing neocortex. Neuroscience . 2017 Jun 3;352:39-51.(IF="3.2769)

28.Xie J, Li X, Zhang W, Chai X, Huang Y, Li K, Cheng X, Zhao S*.Aberrant expression of LIMK1 impairs neuronal migration during neocortex development. Histochem Cell Biol . 2017 Apr;147(4):471-479. (IF="2.5529)

29. Chai X, Fan L, Shao H, Lu X, Zhang W, Li J, Wang J, Chen S, Frotscher M, Zhao S *. Reelin Induces Branching of Neurons and Radial Glial Cells during Corticogenesis. Cerebral Cortex . 2015 ;25(10):3640-53(IF="8.109)

30. Jiutao Wang, Lingzhen Song, Lingling Li, Wei Zhang, Xuejun Chai, Lei. An, Shulin Chen, Michael Frotscher, Shanting Zhao*. SRC controls neuronal migration by regulating the activity of FAK and cofilin.  Neuroscience  2015, 292(1):90–100(IF=3.564)

31. Runchuan Yan,Xinde Hu,Wei Zhang,Lingzhen Song,Jiutao Wang,Yupeng Yin,Shulin Chen,Shanting Zhao*. The mouse radial spoke protein 3 is a nucleocytoplasmic shuttling protein that promotes neurogenesis. Histochem Cell Biol,  2015 Oct;144(4):309-19.(IF="3.054)

32. Wang J, Song L, Zhang Q, Zhang W, An L, Zhang Y, Tong D, Zhao B, Chen S, Zhao S*. Exposure to swainsonine impairs adult neurogenesis and spatial learning and memory.  Toxicology Letters . 2015, 232(1):263–270.(IF="3.355)

33. An L, Song L, Zhang W, Lu X, Chen S, Zhao S*. The aspartic acid of Fyn at 390 is critical for neuronal migration during corticogenesis.  Exp Cell Res.  2014 Nov 1;328(2):419-28.(IF="3.372)

SCI共同作者论文(IF:影响因子)

34.Zeng J, Yu W, Dong X, Zhao S, Wang Z, Liu Y, Wong MS, Wang Y.

Ananoencapsulation suspension biomimetic of milk structure for enhanced maternal and fetal absorptions of DHA to improve early brain development. Nanomedicine. 2019 Jan;15(1):119-128.

35Forster E, Zhao S, Frotscher M. Laminating the hippocampus.  Nat Rev Neurosci.  2006; 7(4):259-267.(IF="31.673)

37.Wang S, Brunne B, Zhao S, Chai X, Li J, Lau J, Failla AV, Zobiak B, Sibbe M, Westbrook GL, Lutz D, Frotscher M.Trajectory Analysis Unveils Reelin's Role in the Directed Migration of Granule Cells in the Dentate Gyrus. J Neurosci . 2018 Jan 3;38(1):137-148.

38.Decker JM, Krüger L, Sydow A, Zhao S, Frotscher M, Mandelkow E, Mandelkow EM. Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation.  Acta Neuropathol Commun. 2015 Apr 3;3:23. (IF="10.762)

39. Frotscher M, Studer D, Graber W, Chai X, Nestel S, Zhao S. Fine structure of synapses on dendritic spines. Front Neuroanat. 2014 Sep 9;8:94.(IF="3.544)

40. Chai X, Münzner G, Zhao S, Tinnes S, Kowalski J, Häussler U, Young C, Haas CA, Frotscher M.Epilepsy-induced motility of differentiated neurons. Cerebral Cortex. 2014 Aug;24(8):2130-40

42. Brunne B, Zhao S, Derouiche A, Herz J, May P, Frotscher M, Bock HH.Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus. Glia.  2010 Oct;58(13):1553-69.

43.Kowalski J, Geuting M, Paul S, Dieni S, Laurens J, Zhao S, Drakew A, Haas CA, Frotscher M, Vida I.Proper layering is important for precisely timed activation of hippocampal mossy cells. Cerebral Cortex. 2010 Sep;20(9):2043-54.

44. Chai X, Förster E, Zhao S, Bock HH, Frotscher M.Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3. J Neurosci.  2009 Jan 7;29(1):288-99.

45. Hack I, Hellwig S, Junghans D, Brunne B, Bock HH, Zhao S, Frotscher M.Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Developmen t. 2007 Nov;134(21):3883-91.

46.Kretz O, Fester L, Wehrenberg U, Zhou L, Brauckmann S, Zhao S, Prange-Kiel J, Naumann T, Jarry H, Frotscher M, Rune GM.Hippocampal synapses depend on hippocampal estrogen synthesis. J Neurosci. 2004 Jun 30;24(26):5913-21.

47. Schwab MH, Bartholomae A, Heimrich B, Feldmeyer D, Druffel-Augustin S, Goebbels S, Naya FJ, Zhao S, Frotscher M, Tsai MJ, Nave KA.Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J Neurosc i. 2000 May 15;20(10):3714-24.


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