周世卫

作者: 来源: 发布日期:2022-09-07 浏览次数:

一.个人基本信息周世卫.jpg

周世卫,男,汉族,籍贯河南省漯河市,中共党员,博士,助理研究员。

二、教育及工作经历

教育经历:

2013年06月毕业于河南工业大学生物工程专业,获理学学士学位;

2016年06月毕业于西北农林科技大学动物科技学院动物营养与饲料科学专业,获农学硕士学位;

2021年06月毕业于西北农林科技大学动物科技学院动物遗传育种与繁殖专业,获农学博士学位;

工作经历:

2021年06月至今在西北农林科技大学兽医学流动站从事博士后科研工作;

2022年06月至今在西北农林科技大学动物医学院临床兽医系从事科研推广工作,助理研究员。

三、研究方向

羊重要经济性状功能基因研究及羊精准基因编辑与种质创新。

四、代表性学术成果

(1)Zhou S, Kalds P, Luo Q, Sun K, Zhao X, Gao Y, Cai B, Huang S, Kou Q, Petersen B, Chen Y, Ma B, Wang X. (2022). Optimized Cas9: sgRNA delivery efficiently generates biallelic MSTN knockout sheep without affecting meat quality. BMC Genomics, 23(1):348.

(2)Zhou S, Ding Y, Liu J, Liu Y, Zhao X, Li G, Zhang C, Li C, Wang Y, Kalds P, Gao Y, Zong B, Huang X, Huang S, Yu H, Kou Q, Petersen B, Huang X, Wang X, Ma B, Chen Y. (2020). Highly efficient generation of sheep with a defined FecBB mutation via adenine base editing. Genetics Selection Evolution, 52(1):35.

(3)Zhou S, Cai B, He C, Wang Y, Ding Q, Liu J, Liu Y, Ding Y, Zhao X, Li G, Li C, Yu H, Kou Q, Niu W, Petersen B, Sonstegard T, Ma B, Chen Y, Wang X. (2019). Programmable Base Editing of the Sheep Genome Revealed No Genome-Wide Off-Target Mutations. Frontiers in Genetics, 10:215.

(4)Zhou S, Yu H, Zhao X, Cai B, Ding Q, Huang Y, Li Y, Niu Y, Lei A, Kou Q, Huang X, Petersen B, Ma B, Chen Y, Wang X. (2018). Generation of gene-edited sheep with a defined Booroola fecundity gene (FecBB) mutation in bone morphogenetic protein receptor type 1B (BMPR1B) via clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) 9. Reproduction Fertility and Development, 30(12):1616-1621.

(5)Li C#, Zhou S#, Li Y#, Li G, Ding Y, Li L, Liu J, Qu L, Sonstegard T, Huang X, Jiang Y, Chen Y, Petersen B, Wang X. (2018). Trio-Based Deep Sequencing Reveals a Low Incidence of Off-Target Mutations in the Offspring of Genetically Edited Goats. Frontiers in Genetics, 9:449.

(6)Li G#, Zhou S#, Li C#, Cai B#, Yu H, Ma B, Huang Y, Ding Y, Liu Y, Ding Q, He C, Zhou J, Wang Y, Zhou G, Li Y, Yan Y, Hua J, Petersen B, Jiang Y, Sonstegard T, Huang X, Chen Y, Wang X. (2019). Base pair editing in goat: nonsense codon introgression into FGF5 results in longer hair. FEBS J, 286(23):4675-4692.

(7)Ding Y#, Zhou S#, Ding Q, Cai Bei, Zhao X, Zhong S, Jin M, Wang X, Ma B, Chen Y. (2020). The CRISPR/Cas9 induces large genomic fragment deletions of MSTN and phenotypic changes in sheep. Journal of Integrative Agriculture, 19(4):1065-1073.

(8)Kalds P, Zhou S, Cai B, Liu J, Wang Y, Petersen B, Sonstegard T, Wang X, Chen Y. (2019). Sheep and Goat Genome Engineering: From Random Transgenesis to the CRISPR Era. Frontiers in Genetics, 10:750.

(9)Zeng J, Zhou S, Yang Y, Du J, Kang D, Wang X, Chen Y. (2020). Effect of dietary nutrition on tail fat deposition and evaluation of tail-related genes in fat-tailed sheep. Electronic Journal of Biotechnology, 46.

(10)Kalds P, Gao Y, Zhou S, Cai B, Huang X, Wang X, Chen Y. (2020). Redesigning small ruminant genomes with CRISPR toolkit: Overview and perspectives. Theriogenology, 147:25.

五、科研项目

1. 中国博士后科学基金面上项目,PE编辑系统的优化及滩羊多胎FecB种质资源的精准创制,2021.01-2022.12,12万,主持;

2. 宁夏科技厅重点项目子课题,双羔滩羊选育及其综合配套技术研发与示范,2021.08-2024.07,15万,主持;

3. 中央引导地方专项子课题,陕北白绒山羊育种核心群的组建与扩繁,2022.01-2022.12,50万,主持;

六、联系方式

地址:陕西省杨陵示范区西农路22号西北农林科技大学动物医学院

邮编:712100

电子邮箱:zhoushiwei66@163.com